This product is freeze dried. All water molecules have been removed.
Control Antigen Included
This antibody is shipped with its antigen FREE of charge!
Alomone Labs is pleased to offer the KV1.3 (KCNA3) Channel Basic Research Pack (#ESB-501). The Research Pack contains all you need for KV1.3 research: Antibodies recognizing different domains of the channel and specific KV1.3 blockers, all in one economical package!
KV1.3 belongs to the Shaker family of voltage-dependent K+ channels. The channel, encoded by KCNA3, is widely expressed in the brain, lung and osteoclasts and in several cell populations of hematopoietic origin. It is in these cells (particularly T lymphocytes) that KV1.3 function has centered a lot of attention. It was found that KV1.3 is the main channel
Responsible for maintaining the resting potential in quiescent cells and regulating the Ca2+ signaling that is indispensable for normal T lymphocyte activation.1,2
Based on the central role of Kv1.3 in regulating the initiation of an immune response, the channel has been recognized as a potential target for immunosuppressant drugs.1
KV1.3 channels are potently inhibited by several venomous peptide toxins among them Charybdotoxin (#STC-325, 2.6 nM), Noxiustoxin (#STN-340, 1 nM), Kaliotoxin (#STK-370, 0.65 nM), Margatoxin (#STM-325, 0.05 nM), Agitoxin-1 (#RTA-150, 1.7 nM), Agitoxin-2 (#STA-420, 0.004 nM), Hongotoxin-1 (#RTH-400, 0.09 nM) and Stichodactyla toxin (#STS-400, 0.01 nM).3-7
Chandy, K.G. et al. (2001) Toxicon 39, 1269.
Koo, G.C. et al. (1997) J. Immunol. 158, 5120.
Grissmer, S. et al. (1994) Mol. Pharmacol. 45, 1227.
Garcia-Calvo, M. et al. (1993) J. Biol. Chem. 268, 18866.
Garcia, M.L. et al. (1994) Biochemistry 33, 6834.
Koschak, A. et al. (1998) J. Biol. Chem. 273, 2639.
Kalman, K. et al. (1998) J. Biol. Chem. 273, 32697.
- KV1.3 (KCNA3) Channel Premium Research Pack (#ESP-501)
- KV1.3 (KCNA3) Channel Deluxe Research Pack (#ESD-501)
- Anti-KV1.3 (KCNA3) (extracellular)-Biotin Antibody (#APC-101-B)
- Anti-KV1.3 (KCNA3) (extracellular)-FITC Antibody (#APC-101-F)
- Guinea pig Anti-KV1.3 (KCNA3) (extracellular) Antibody (#AGP-005)
- Agitoxin-2-Cys-TAMRA (#RTA-420-T)
- ADWX-1 (#STW-100)
- HsTx1 Toxin (#STH-300)
- Margatoxin (#STM-325)