KV1.3 (KCNA3) Channel Deluxe Research Pack

All You Need for KV1.3 (KCNA3) Channel Research
  • Lyophilized Powder
  • Antigen Incl.
  • Bioassay Tested
  • Shipped at Room Temp.
  • 100% Net Peptide
Cat #: ESD-501
Sizes: 11 Vials
Last update: 14/10/2018

Alomone Labs is pleased to offer the KV1.3 (KCNA3) Channel Deluxe Research Pack (#ESD-501). The Research Pack contains all you need for KV1.3 research: Antibodies recognizing different domains of the channel and specific KV1.3 blockers, all in one economical package!

For research purposes only, not for human use
Compounds
Product NameCat #Size
Anti-KV1.3 (KCNA3) Antibody
APC-002 1 x 0.2 ml
Anti-KV1.3 (KCNA3) (extracellular) Antibody
APC-101 1 x 0.2 ml
Anti-KV1.3 (KCNA3) (extracellular)-Biotin Antibody
APC-101-B 1 x 50 µl
Guinea pig Anti-KV1.3 (KCNA3) (extracellular) Antibody
AGP-005 1 x 0.2 ml
Aam-KTX
STA-110 1 x 0.1 mg
ADWX-1
STW-100 1 x 0.1 mg
Agitoxin-2
STA-420 1 x 0.1 mg
Note A guinea pig polyclonal antibody (#AGP-005) is included in this Research Pack. Please take into account when reacting with a secondary antibody.
Scientific Background
Scientific Background

KV1.3 belongs to the Shaker family of voltage-dependent K+ channels. The channel, encoded by KCNA3, is widely expressed in the brain, lung and osteoclasts and in several cell populations of hematopoietic origin. It is in these cells (particularly T lymphocytes) that KV1.3 function has centered a lot of attention. It was found that KV1.3 is the main channel  

Responsible for maintaining the resting potential in quiescent cells and regulating the Ca2+ signaling that is indispensable for normal T lymphocyte activation.1,2  

Based on the central role of Kv1.3 in regulating the initiation of an immune response, the channel has been recognized as a potential target for immunosuppressant drugs.1 

KV1.3 channels are potently inhibited by several venomous peptide toxins among them Charybdotoxin (#STC-325, 2.6 nM), Noxiustoxin (#STN-340, 1 nM), Kaliotoxin (#STK-370, 0.65 nM), Margatoxin (#STM-325, 0.05 nM), Agitoxin-1 (#RTA-150, 1.7 nM), Agitoxin-2 (#STA-420, 0.004 nM), Hongotoxin-1 (#RTH-400, 0.09 nM)  and Stichodactyla toxin (#STS-400, 0.01 nM).3-7

References
  1. Chandy, K.G. et al. (2001) Toxicon 39, 1269.
  2. Koo, G.C. et al. (1997) J. Immunol. 158, 5120.
  3. Grissmer, S. et al. (1994) Mol. Pharmacol. 45, 1227.
  4. Garcia-Calvo, M. et al. (1993) J. Biol. Chem. 268, 18866.
  5. Garcia, M.L. et al. (1994) Biochemistry 33, 6834.
  6. Koschak, A. et al. (1998) J. Biol. Chem. 273, 2639.
  7. Kalman, K. et al. (1998) J. Biol. Chem. 273, 32697.
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