NMDA Receptor Antagonist Explorer Kit

A Screening Package of NMDA Receptor Antagonists Economically Priced
  • Lyophilized Powder
  • Bioassay Tested
Cat #: EK-350
Sizes: 17 Vials
Last update: 25/09/2019

Alomone Labs is pleased to offer the NMDA Receptor Antagonist Explorer Kit (#EK-350). The Explorer Kit contains NMDA receptor antagonists, ideal for screening purposes.

For research purposes only, not for human use
Compounds
Product NameCat #Size
7-Chlorokynurenic acid sodium salt
C-286 1 x 5 mg
α-Asarone
A-260 1 x 1 g
Arcaine sulfate
A-285 1 x 25 mg
CGS 19755
C-310 1 x 5 mg
CNS-1102
C-305 1 x 5 mg
(±)-CPP
C-175 1 x 5 mg
D-AP5
D-145 1 x 1 mg
DL-AP5
D-140 1 x 5 mg
Eliprodil
E-155 1 x 5 mg
Ifenprodil (+)-tartrate salt (hemitartrate salt)
I-105 1 x 5 mg
Kynurenic acid
K-110 1 x 1 g
Loperamide hydrochloride
L-100 1 x 5 g
Memantine hydrochloride
M-145 1 x 50 mg
(+)-MK 801 maleate
M-230 1 x 5 mg
Orphenadrine citrate salt
O-100 1 x 1 g
Orphenadrine hydrochloride
O-101 1 x 5 g
Pentamidine isethionate salt
P-155 1 x 100 mg
References
    • The NMDA receptors are members of the glutamate receptor family of ion channels that also include the AMPA and Kainate receptors.

      The NMDA receptors are encoded by seven genes: one NMDAR1 (or NR1) subunit, four NR2 (NR2A-NR2D) and two NR3 (NR3A-NR3B) subunits. The functional NMDA receptor appears to be a heterotetramer composed of two NMDAR1 and two NMDAR2 subunits. Whereas the NMDAR2 subunits that assemble with the NMDAR1 subunit can be either of the same kind (i.e. two NMDAR2A subunits) or different (one NMDAR2A with one NMDAR2B). NMDAR3 subunits can substitute the NMDAR2 subunits in their complex with the NMDAR1 subunit.

      The NMDAR is unique among ligand-gated ion channels in that it requires the simultaneous binding of two obligatory agonists: glycine and glutamate that bind to the NMDAR1 and NMDAR2 binding sites respectively. Another unique characteristic of the NMDA receptors is their dependence on membrane potential. At resting membrane potentials the channels are blocked by extracellular Mg2+. Neuronal depolarization relieves the Mg2+ blockage and allows ion influx into the cells. NMDA receptors are strongly selective for Ca2+ influx differing from the other glutamate receptor ion channels that are non-selective cation channels.

      Ca2+ entry through the NMDAR regulates numerous downstream signaling pathways including long term potentiation (a molecular model of memory) and synaptic plasticity that may underlie learning. In addition, the NMDA receptors have been implicated in a variety of neurological disorders including epilepsy, ischemic brain damage, Parkinson’s and Alzheimer’s diseases.

      NMDA receptor expression and function are modulated by a variety of factors including receptor trafficking to the synapses and internalization as well as phosphorylation and interaction with other intracellular proteins.

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