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trans-ACBD

1-Aminocyclobutane-1,3-dicarboxylic acid

An Agonist of NMDA Receptors

Cat #: A-280
Alternative Name 1-Aminocyclobutane-1,3-dicarboxylic acid
Lyophilized Powder yes
  • Bioassay Tested
    • Source Synthetic
    MW: 159.14
    Purity: >95%
    Form Lyophilized powder.
    Effective concentration 0.1-20 µM.
    Structure
    Chemical name 1-aminocyclobutane-1,3-dicarboxylic acid.
    Molecular formula C6H9NO4.
    CAS No.: 117488-23-0
    Activity trans-ACBD is an NMDA receptor agonist1,2.
    References-Activity
    1. Allan, R.D. et al. (1990) J. Med. Chem. 33, 2905.
    2. Erreger, K. et al. (2007) Mol. Pharmacol. 72, 907.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 500 mM in H2O. Centrifuge all product preparations before use (10,000 x g for 1 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs trans-ACBD activates NMDA receptors (NR1+NR2A) expressed in Xenopus oocytes. 
      Alomone Labs trans-ACBD activates NMDA receptors (NR1+NR2A) expressed in Xenopus oocytes. 
      Time course of NMDA receptor current activation by 2 and 10 μM trans-ACBD (#A-280) (at -80 mV). For comparison, a solution containing 10 µM glutamate and 10 µM glycine was applied for 2.5 min resulting in currents of comparable amplitude (as indicated). Amplitude change as a result of the application of raising concentrations of trans-ACBD (perfusion duration indicated by the horizontal bar, concentration as indicated).
    References - Scientific background
    1. Fletcher, E.J. et al. (1991) Neurosci. Lett. 121, 133.
    2. Allan, R.D. et al. (1990) J. Med. Chem. 33, 2905.
    3. Talukder, I. et al. (2010) J. Neurosci. 30, 11792.
    Scientific background

    trans-ACBD is a potent, competitive and selective activator of glutamate uptake. The compound acts as an NMDA (N-methyl-D-aspartate) receptor agonist. The ACBD structure includes two isomers: cis-1-aminocyclobutane-1,3-dicarboxylic acid and trans-1-aminocyclobutane-1,3-dicarboxylic acid. Several studies have shown that the trans isomer is more potent than the cis isomer. The trans isomer was also shown to be 20 times more active than NMDA1,2, the major excitatory neurotransmitter in the mammalian central nervous system (CNS).

    Several studies suggest that modifications and changes of glutamate uptake could play a role in processes underlying synaptic plasticity in the CNS2.

    NMDA receptors are ion channels gated by glutamate. Glutamate-mediated signaling is important for basic neuron-neuron signaling and neuronal processes such as learning, memory and pain perception3.

    Target NMDA receptors
    Lyophilized Powder
    Last update: 06/11/2022

    trans-ACBD (#A-280) is a highly pure, synthetic, and biologically active compound.

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    For research purposes only, not for human use

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