Every lot is tried & tested in a relevant biological assay.
Our Bioassay
- Allan, R.D. et al. (1990) J. Med. Chem. 33, 2905.
- Erreger, K. et al. (2007) Mol. Pharmacol. 72, 907.
- Alomone Labs trans-ACBD activates NMDA receptors (NR1+NR2A) expressed in Xenopus oocytes.Time course of NMDA receptor current activation by 2 and 10 μM trans-ACBD (#A-280) (at -80 mV). For comparison, a solution containing 10 µM glutamate and 10 µM glycine was applied for 2.5 min resulting in currents of comparable amplitude (as indicated). Amplitude change as a result of the application of raising concentrations of trans-ACBD (perfusion duration indicated by the horizontal bar, concentration as indicated).
- Fletcher, E.J. et al. (1991) Neurosci. Lett. 121, 133.
- Allan, R.D. et al. (1990) J. Med. Chem. 33, 2905.
- Talukder, I. et al. (2010) J. Neurosci. 30, 11792.
trans-ACBD is a potent, competitive and selective activator of glutamate uptake. The compound acts as an NMDA (N-methyl-D-aspartate) receptor agonist. The ACBD structure includes two isomers: cis-1-aminocyclobutane-1,3-dicarboxylic acid and trans-1-aminocyclobutane-1,3-dicarboxylic acid. Several studies have shown that the trans isomer is more potent than the cis isomer. The trans isomer was also shown to be 20 times more active than NMDA1,2, the major excitatory neurotransmitter in the mammalian central nervous system (CNS).
Several studies suggest that modifications and changes of glutamate uptake could play a role in processes underlying synaptic plasticity in the CNS2.
NMDA receptors are ion channels gated by glutamate. Glutamate-mediated signaling is important for basic neuron-neuron signaling and neuronal processes such as learning, memory and pain perception3.
trans-ACBD (#A-280) is a highly pure, synthetic, and biologically active compound.
Applications
Citations
Specifications
Scientific Background
Related Products
Antibodies
- Anti-NMDAR1 (GluN1) (extracellular) Antibody (#AGC-001)
- Guinea pig Anti-NMDAR1 (GluN1) (extracellular) Antibody (#AGC-001-GP (formerly AGP-046))
- Anti-NMDAR2A (GluN2A) (extracellular) Antibody (#AGC-002)
- Anti-NMDAR2B (GluN2B) (extracellular) Antibody (#AGC-003)
- Anti-NMDAR2B (GluN2B) (extracellular)-ATTO Fluor-594 Antibody (#AGC-003-AR)
- Anti-NMDAR2C (GRIN2C) (extracellular) Antibody (#AGC-018)
- Anti-NMDAR2D (GRIN2D) (extracellular) Antibody (#AGC-020)
- Anti-NMDAR3A (GRIN3A) (extracellular) Antibody (#AGC-030)
- Anti-NMDAR3B (GRIN3B) (extracellular) Antibody (#AGC-031)
Pharmacological tools
- CGP-37849 (#C-325)
- (±)-CPP (#C-175)
- D-AP5 (#D-145)
- DL-AP5 (#D-140)
- DQP-1105 (#D-210)
- Ifenprodil (+)-tartrate salt (hemitartrate salt) (#I-105)
- Kynurenic acid (#K-110)
- Memantine hydrochloride (#M-145)
- (+)-MK 801 maleate (#M-230)
- Pentamidine isethionate salt (#P-155)
- QNZ 46 (#Q-270)
- Ro 25-6981 maleate (#R-180)
Explorer kits & Research packs
Need Help With This Product?
Our reagent specialists are here to help you find the best product for your application. Please call or email us and we will be happy to help you find the right product for the job.
Call us at
+972 2587 2202 or Email Us