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Nonivamide

Pelargonic acid vanillylamide/PAVA

A Potent Activator of TRPV1 Channels

Cat #: N-220
Alternative Name Pelargonic acid vanillylamide/PAVA
Lyophilized Powder yes
  • Bioassay Tested
    • Source Synthetic
    MW: 293.4
    Purity: >98%
    Effective concentration 100 nM - 10 µM.
    Structure
    Chemical name N-[(4-hydroxy-3-methoxyphenyl)methyl]nonanamide.
    Molecular formula C17H27NO4.
    CAS No.: 2444-46-4
    Activity Nonivamide is a TRPV1 activator1.
    References-Activity
    1. Thomas, K.C. et al. (2011) J. Pharmacol. Exp. Ther. 337, 400.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs Nonivamide activates TRPV1 channels heterologously expressed in C-6 cells.
      Alomone Labs Nonivamide activates TRPV1 channels heterologously expressed in C-6 cells.
      Cells were loaded with Fluo-3 AM and changes in intracellular Ca2+ were detected. Normalized fluorescence before (control, gray dotted line) and after application of 0.1, 1 and 10 µM Nonivamide (#N-220), (as indicated).
    References - Scientific background
    1. Zhao, J. et al. (2006) Biochemistry 45, 4915.
    2. Ryskamp, D.A. et al. (2014) Cells 12, 9141.
    Scientific background

    Nonivamide is a synthetic analog of capsaicin, a pungent ingredient in chili peppers. It binds to TRPV1 channel and activates it with high potency (EC50 ≈ 10-7 M). Treatment with nonivamide activates TRPV1 channels, allowing non-selective cation flux into neurons, causing membrane depolarization and increase in cytosolic Ca2+ due to release of Ca2+ from the endoplasmic reticulum1.

    TRPV1 is a member of the TRP family of ion-channels and found throughout the body in epithelial cells and in peripheral and central terminals in neurons. The TRPV family includes six mammalian ion channels, TRPV1-TRPV6. TRPV1 is a Ca2+-permeable channel which is activated and modulated by a variety of exogenous stimuli such as heat, changes in pH, and irritant and pungent compounds and by selected molecules released during inflammatory processes and tissue damage2.

    Target TRPV1 channels
    Lyophilized Powder
    Last update: 25/07/2021

    Nonivamide (#N-220) is a highly pure, synthetic, and biologically active compound.

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    For research purposes only, not for human use
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