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An Activator of TRPV1 Channel

Cat #: O-120
Alternative Name N-oleoyl-dopamine
Lyophilized Powder yes
  • Bioassay Tested
  • Source Synthetic
    MW: 417.6
    Purity: >96%
    Form Lyophilized powder.
    Effective concentration 0.5 nM – 50 µM.
    Chemical name (Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]octadec-9-enamide.
    Molecular formula C26H43NO3.
    CAS No.: 105955-11-1
    Activity OLDA activates TRPV1 channels with an EC50 ~ 0.36 µM1.
    1. Chu, C.J. et al. (2003) J. Biol. Chem. 278, 136333.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Ethanol and DMSO up to 50 mM. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs OLDA activates TRPV1 channels heterologously expressed in C-6 cells.
      Alomone Labs OLDA activates TRPV1 channels heterologously expressed in C-6 cells.
      Cells were loaded with Fluo-3AM and changes in intracellular Ca2+ were detected. Normalized fluorescence before (control) and after application, at 20 seconds (arrow), of 1-100 µM OLDA (#O-120), (as indicated).
    References - Scientific background
    1. Zajac, D. et al. (2006) J. Physiol. Pharmacol. 57, 403.
    2. Zhong, B. et al. (2008) Am. J. Physiol. 295, H728.
    3. Walker, J.M. et al. (2005) Prostaglandins Other Lipid Mediat. 77, 35.
    4. Chu C.J. et al. (2003) J. Biol. Chem. 278, 13633.
    5. Konieczny, J. et al. (2009) Int. J. Immunopathol. Pharmacol. 22, 21.
    Scientific background

    OLDA is an amide of dopamine (DA) and oleic acid. It is a member of the family of N-acyl-dopamines that are recognized as novel biologically active lipid derivatives of dopamine1.

    The transient receptor potential vanilloid 1 (TRPV1) channel is a nonselective cation channel mainly expressed in primary sensory neurons and sensory C- and A- fibers. TRPV1 can be activated by physical and chemical stimuli, including noxious heat, protons, vanilloid compounds or endogenous arachidonic acid derivatives such as N-oleoyldopamine (OLDA)2.

    OLDA has been found in striatal, dorsal spinal cord, and dorsal root ganglia3 and identified as the most selective and potent endogenous TRPV1 activator so far with EC values of 36 nM4. OLDA is increasingly recognized as an important class of signaling molecules affecting pain, inflammation, and tissue injury3. Recent studies have shown that OLDA could have a potential role in treating DA-related disorders, such as Parkinson's disease (PD)5.

    Target TRPV1 channels
    Last update: 02/01/2022

    OLDA (#O-120) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
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