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An Activator of TRPV1 Channel and Cannabinoid Receptors

Cat #: O-115
Lyophilized Powder yes
  • Bioassay Tested
  • Source Synthetic
    MW: 417.6
    Purity: >99%
    Form Lyophilized powder.
    Effective concentration 0.5 nM - 50 µM.
    Chemical name N-Vanillyloleoylamide.
    Molecular formula C26H43NO3.
    CAS No.: 58493-49-5
    Activity Olvanil is an opener of TRPV1 channels (EC50 ~ 0.001 µM)1 and an activator of Cannabinoid receptors2.
    1. Vriens, J. et al. (2009) Mol. Pharmacol. 75, 1262.
    2. Di Marzo, V. et al. (1998) FEBS Lett. 436, 449.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Ethanol (up to 20.9 mg/ml). Centrifuge all product preparations before use (10000 x g for 1 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs Olvanil activates TRPV1 channels heterologously expressed in C-6 cells.
      Alomone Labs Olvanil activates TRPV1 channels heterologously expressed in C-6 cells.
      Cells were loaded with Fluo-3 AM and changes in intracellular Ca2+ were detected. Normalized fluorescence before and after application, at 20 seconds (arrow), of 1 nM - 10 µM Olvanil (#O-115), (as indicated).
    References - Scientific background
    1. Basbaum, A.I. et al. (2009) Cell 139, 267.
    2. Chu, K.M. et al. (2010) Neuropharmacology 58, 383.
    3. Tomohiro, D. et al. (2013) Life Sci. 92, 368.
    4. Brand, L. et al. (1987) Drugs Expl. Clin. Res. 13, 259.
    5. Walpole, C.S. et al. (1993) in Capsaicin in the study of pain, ed Wood J (Academic, London), 63.
    6. Campbell, E. et al. (1993) in Capsaicin in the study of pain, ed Wood J (Academic, London), 259.
    7. Liu, L. et al. (1997) J. Neurosci. 17, 4101.
    8. Di Marzo, V. et al. (1998) FEBS Lett. 436, 449.
    Scientific background

    The pungent transient receptor potential vanilloid (TRPV1) is a nonspecific cation channel located on neurons involved in nociceptive transduction. One of its main peripheral physiological functions is the transduction of heat. It can also be activated by protons (low pH) and capsaicin (8-methyl-N-vanillyl-noneamid)1. Central TRPV1 receptors are involved in the regulation of body temperature, emesis, and pain2.

    Olvanil N-(3- methoxy-4-hydroxybenzyl)oleamide, capsaicin analogs, is a potent agonist of TRPV1 channel3. Olvanil, like capsaicin, has antinociceptive and anti-inflammatory properties4, and is equipotent with capsaicin in its ability to increase Ca2+ influx in cultured rat DRGs5, and in behavioral measurements of pain6. Olvanil was found to be 10 times more potent than capsaicin as a vasodilator7.

    Olvanil is also known to inhibit cannabinoid receptors8.

    Target TRPV1 channels, Cannabinoid receptors
    Last update: 06/11/2022

    Olvanil (#O-115) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
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