Overview
Cat #:
STC-150
Alternative Name ω-conotoxin MoVIA
Lyophilized Powder yes
Origin Conus moncuri (Sea snail)
Source Synthetic peptide
MW: 3607 Da
Purity: >98%
Form Lyophilized Powder
Effective concentration 100 nM – 2 µM
Sequence CKPXGSKCSXSMRDCCTTCISYTKRCRKYYN-OH
Modifications X = Hydroxyproline
Disulfide bonds location - Cys1-Cys16, Cys8-Cys19, Cys15-Cys26
Molecular formula C147H233N45O47S7
Activity A selective Cav2.2 blocker1
Accession number A0A384E129 Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C. Protect from light and moisture.
Solubility Soluble in water. It is recommended to prepare fresh solutions in working buffers before use, or aliquot stock solutions reconstituted in distilled water and keep at -20°C. Upon use, dilute the stock solution in the desired working buffer. Prevent repeated thawing and freezing cycles. Centrifuge all product preparations before use (10,000 g for 1 min).
Storage of solutions Store up to one week at 4°C or up to 6 months at -20°C.
Scientific background ω-conotoxin MoVIA (MoVIA) is a 29 amino acid peptidyl toxin originally isolated from the venom of the western Pacific vermivorous (worm-hunting) cone snail, Conus moncuri. MoVIA is a specific and potent blocker of mammalian N-type voltage-gated Ca2+ channels (CaV2.2)1.
MoVIA has an arginine at position 13 instead of a tyrosine, which has been previously shown to be functionally critical for the potent Cav2.2 inhibitor activity of ω-conotoxins including ω-conotoxin MVIIA (#C-670) and ω-conotoxin GVIA (#C-300) from piscivorous (fish-hunting) species1.
CaV2.2 are predominantly expressed in nerve terminals and are involved in the regulation of neuronal excitability and nociceptive signaling. These channels are multifunctional and play important roles in the transduction of acute and chronic pain perception. They are able to transduce electrical activity into other cellular functions, regulate calcium homeostasis and process pain information. Since ω-conotoxins selectively inhibit Cav2.2 in nociceptors, they are considered attractive molecules for drug design2.
Target Cav2.2
Peptide Content: 100%
Lyophilized Powder
For research purposes only, not for human use
Last Update: 02/01/2024