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(S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

An Agonist of AMPA Receptors

Cat #: A-267
Alternative Name (S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
Lyophilized Powder yes
  • Bioassay Tested
  • Source Synthetic
    MW: 186.17
    Purity: >99% (HPLC)
    Effective concentration 0.01-10 µM.
    Chemical name (2S)-2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid.
    Molecular formula C7H10N2O4.
    CAS No.: 83643-88-3
    PubChem CID 158397
    Activity An active enantiomer of AMPA (EC50 = 3.5 μM)1.
    1. Falch, E. et al. (1998) J. Med. Chem. 41, 2513.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 100 mM in H2O. Centrifuge all products before reconstitution (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C. It is recommended to aliquot reconstituted stock solutions.
    Our bioassay
    • Alomone Labs (S)-AMPA activates GluA1 channels expressed in Xenopus oocytes. 
      Alomone Labs (S)-AMPA activates GluA1 channels expressed in Xenopus oocytes. 
      Time course of current, reversibly activated by 1 µM and 10 µM (S)-AMPA (#A-267) as indicated, while membrane potential was held at -80 mV.
    References - Scientific background
    1. Falch, E. et al. (1998) J. Med. Chem. 41, 2513.
    2. Guntupalli, S. et al. (2016) Neural. Plast. 2016, 3204519.
    Scientific background

    (S)-AMPA enantiomer is a synthetic AMPA receptor agonist. The compound mimics the effects of the glutamate neurotransmitter1.

    Ionotropic glutamate AMPA receptors (AMPARs) are the primary receptors that mediate fast excitatory synaptic transmission in the mammalian brain. The majority of this transmission in the mammalian central nervous system is mediated by the release of glutamate from the presynaptic terminal and its binding to glutamate receptors on the postsynaptic membrane2.

    Target AMPA receptors
    Last update: 03/01/2023

    (S)-AMPA (#A-267) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
    Shipping and Ordering information