GABA(A) Receptor Antibody Explorer Kit

A Screening Package of GABA(A) Receptor Antibodies Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
  • Shipped at Room Temp.
Cat #: AK-229
Sizes: 32 Vials
Last update: 03/09/2018

Alomone Labs is pleased to offer the GABA(A) Receptor Antibody Explorer Kit (#AK-229). This Explorer Kit includes antibodies targeting GABA(A) receptors along with their respective peptide control antigen. An ideal tool for screening purposes.

For research purposes only, not for human use
Compounds
Scientific Background
Scientific Background

GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. Its production, release, reuptake, and metabolism all occur in the nervous system1.

The GABA transmitter interacts with two major types of receptors: ionotropic GABAA receptors (GABAAR) and metabotropic receptors (GABABR). GABAARs belong to the ligand-gated ion channel superfamily2. GABA inhibits the activity of signal-receiving neurons by interacting with the GABAA receptor on these cells3. Binding of GABA to its GABAA receptor results in conformational changes that open a Cl- channel, producing an increase in membrane conductance that results in inhibition of neural activity2.

GABAARs are heteropentamers, in which all five subunits contribute to pore formation. To date, eight subunit isoforms have been cloned: α, β, γ, δ, ε, π, θ, and ρ1. Six α subunit isoforms have been found to exist in mammals (α1-α6). In most cases, native GABAA receptors consist of 2α, 2β, and 1δ subunits. The α subunit is the most common and is expressed ubiquitously. It determines the affinities of GABAARs for allosteric ligands.

References
  1. Owens, D.F. et al. (2002) Nat. Rev. Neurosci3, 715.
  2. Whiting, P.J. (1999) Neurochem. Int. 34, 387.
  3. Mihic, S.J. et al. (1997) Alcohol Health Res. World 21, 127.
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