Endothelin Receptor Pharmacology Explorer Kit

A Screening Package of Endothelin Receptor Pharmacology Economically Priced
  • Lyophilized Powder
  • Bioassay Tested
  • Shipped at Room Temp.
  • 100% Net Peptide
Cat #: EK-257
Sizes: 19 Vials
Last update: 03/09/2018

Alomone Labs is pleased to offer the Endothelin Receptor Pharmacology Explorer Kit (#EK-257). The Explorer Kit contains endothelin receptor agonists and antagonists, ideal for screening purposes.

For research purposes only, not for human use
Compounds
Product NameCat #Size
A-192621
A-360 1 x 1 mg
ACT-132577
A-350 1 x 5 mg
Atrasentan
A-455 1 x 1 mg
Avosentan
A-355 1 x 5 mg
BMS 182874 hydrochloride
B-500 1 x 5 mg
Bosentan hydrate
B-170 1 x 25 mg
BQ788
B-175 1 x 0.5 mg
BQ788 sodium salt
B-176 1 x 0.5 mg
BQ-123 sodium salt
B-185 1 x 5 mg
BQ-3020
SPE-200 1 x 5 mg
Darusentan
D-265 1 x 5 mg
[Ala1,3,11,15] Endothelin-1
SPE-240 1 x 5 mg
IRL-1620
SPE-220 1 x 5 mg
IRL 2500
I-190 1 x 5 mg
Ro46-8443
R-185 1 x 1 mg
Sarafotoxin S6b
SPE-160 1 x 0.1 mg
SB209670
S-205 1 x 0.5 mg
TAK-044
SPE-320 1 x 5 mg
Zibotentan
Z-130 1 x 5 mg
References
Scientific Background

The endothelin system is comprised of three active peptides, ET-1, 2, and 3, which are considered to be very powerful vasoconstrictive substances. In humans, endothelins mediate their actions via two specific G-Protein Coupled Receptors, ETAR and ETBR. Both ETAR and ETBR are present in heart and in human myocardium at similar levels.1,2

The endothelin receptors differ in their ligand specificity. While ETAR has varying affinities for the endothelin isoforms (ET-1 >ET-2>ET-3), ETBR shows no selective affinity.2,3 Subsequent studies have demonstrated the presence of endothelins in vascular as well as in non-vascular cells and tissues, having multiple biological activities.

References
  1. Boivin, Bet al. (2003) J. Biol.Chem. 278, 29153.
  2. Grant, Ket al. (2003) Br. J. Cancer88, 163.
  3. Davenport, A.P. (2002) Pharmacol. Rev54, 219.
  4. Asham, Eet al. (2001) Br. J. Cancer. 85, 1759.
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