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NBQX disodium salt

An Antagonist of AMPA/Kainate Receptors

Cat #: N-186
Lyophilized Powder yes
  • Bioassay Tested
  • Source Synthetic
    MW: 380.2
    Purity: >99%
    Effective concentration 0.1- 500 µM.
    Chemical name 2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt.
    Molecular formula C12H6N4Na2O6S.
    CAS No.: 479347-86-9
    Activity NBQX is a potent inhibitor of non-NMDA glutamate receptor channels exhibiting IC50s of 0.1-0.4 μM for AMPA and 1.7-8 μM for kainate receptors1.
    1. Traynelis, S.F. et al. (2010) Pharmacol. Rev. 62, 405.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Water. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs NBQX disodium salt inhibits GluA1 channels expressed in Xenopus oocytes.
      Alomone Labs NBQX disodium salt inhibits GluA1 channels expressed in Xenopus oocytes.
      Representative time course of GluA1 current, activated by a continuous application (top dotted line) of 10 µM glutamate, and reversibly inhibited by 5 µM NBQX disodium salt (#N-186), as indicated (horizontal bar), at a holding potential of -60 mV.
    References - Scientific background
    1. Joshi, P.P. et al. (2012) Int. J. Pharmacy Pharmaceutical Sci. 4, 45.
    2. Hollmann, M. and Heinemann, S. (1994) Annu. Rev. Neurosci. 17, 31.
    3. Goldstein, J.M. and Litwin, L.C. (1993) Mol. Chem. Neuropathol. 18, 145.
    4. Filliat, P. et al. (1998) Pharmacol. Biochem. Behavior 59, 1087.
    5. Sheardown M.J. et al. (1990) Science 247, 571.
    6. Robichaud L.J. et al. (1991) Neurosci. Abst. 17, 1168.
    7. Dzubay, J.A. and Jahr, C.E. (1999) J. Neurosci. 19, 5265.
    8. Traynelis, S.F. et al. (2010) Pharmacol. Rev. 62, 405.
    Scientific background

    The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor) is a non-N-methyl-D-aspartate (non-NMDA) type ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the central nervous system (CNS)1. AMPA receptors normally assemble from four genetically distinct subunits: GluR1GluR2GluR3, and GluR4, which combine to form receptor complexes with different functional properties2.

    NBQX (2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F) quinoxaline) is an analogue of the quinoxalinedione antagonists to the non-NMDA glutamate receptor. NBQX is a potent and selective inhibitor of binding to the quisqualate subtype of the glutamate receptor, with no activity at the NMDA and glycine site3. It is a specific and potent AMPA receptor antagonist and has been found to be neuroprotective in various models of ischemia and to have anticonvulsant properties in different models of epilepsy4. NBQX has been reported to block the excitatory actions of AMPA in rat neocortex slices while having no effect on NMDA responses5. It was also reported to selectively block AMPA-induced depolarizations but not spontaneous epileptiform discharges in Mg2+ free medium in the rat cortical wedge6. NBQX blocks AMPA and kainate receptors at micromolar concentrations7,8.

    Target AMPA/Kainate receptors
    Last update: 22/01/2023

    NBQX disodium salt (#N-186) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use



    Product citations
    1. Ruda-Kucerova, J. et al. (2018) Neurosci. Lett. 666, 175.
    2. Irie, T. and Trussell, L.O. (2017) Neuron 96, 856.
    3. Murphy, T.R. et al. (2017) Front. Cell. Neurosci. 11, 275.
    4. Zhu, J. et al. (2017) PLoS Genet. 13, e1006634.
    5. Libbey, J.E. et al. (2016) Exp. Neurol. 280, 89.


    Scientific Background

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