TRPC Channel Antibody Explorer Kit

A Screening Package of TRPC Channel Antibodies Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
Cat #: AK-212
Sizes: 24 Vials
Last update: 20/11/2019

Alomone Labs is pleased to offer the TRPC Channel Antibody Explorer Kit (#AK-212). The Explorer Kit contains TRPC channel antibodies, ideal for screening purposes.

For research purposes only, not for human use
Compounds
Product NameCat #Size
Anti-TRPC1 Antibody
ACC-010 1 x 50 µl
Anti-TRPC1 (extracellular) Antibody
ACC-118 1 x 50 µl
Anti-TRPC2 Antibody
ACC-027 1 x 50 µl
Anti-TRPC3 Antibody
ACC-016 1 x 50 µl
Guinea pig Anti-TRPC3 Antibody
AGP-018 1 x 50 µl
Anti-TRPC4 Antibody
ACC-018 1 x 50 µl
Anti-TRPC4 (extracellular) Antibody
ACC-119 1 x 50 µl
Anti-TRPC5 Antibody
ACC-020 1 x 50 µl
Anti-TRPC6 Antibody
ACC-017 1 x 50 µl
Guinea pig Anti-TRPC6 Antibody
AGP-002 1 x 50 µl
Anti-TRPC6 (extracellular) Antibody
ACC-120 1 x 50 µl
Anti-TRPC7 (extracellular) Antibody
ACC-066 1 x 50 µl
Note Guinea pig polyclonal antibodies (#AGP-018 & #AGP-002) are included in this Explorer Kit. Please take into account when reacting with a secondary antibody.
Scientific Background
    • The Transient Receptor Potential (TRP) superfamily is one of the largest ion channel families and consists of diverse groups of proteins. In mammals about 28 genes encode the TRP ion channel subunits. The mammalian TRP superfamily comprises six subfamilies known as the TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPML (mucolipins), TRPP (polycystin) and the TRPA (ANKTM1) ion channels.1-4

      The TRPC subfamily consists of seven proteins named TRPC1 to 7, which can be further divided into four subgroups based on their sequence homology and functional similarities:
      1.) TRPC1 2.) TRPC4 and TRPC5 3.) TRPC3, TRPC6, TRPC7 4.) TRPC2.2,5 They are highly expressed in the central nervous system and to a lesser extent in peripheral tissues.

      The TRPC1, TRPC4 and TRPC5 can be activated either by Ca2+ store depletion or by GPCR stimulation pathways, while TRPC3, TRPC6 and TRPC7 form non-selective cationic channels that are activated by the stimulation of GPCRs. TRPC1, 4 and TRPC5 are assumed to form components of store operated channels in some cell types such as salivary gland cells, endothelial cells and vascular smooth muscle cells.6

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