TRPV1 Channel Basic Research Pack

All You Need for TRPV1 Channel Research
  • Lyophilized Powder
  • Antigen Incl.
Cat #: ESB-300
Sizes: 7 Vials
Last update: 31/07/2019

Alomone Labs is pleased to offer the TRPV1 Channel Basic Research Pack (#ESB-300). The Research Pack contains all you need for TRPV1 research: Antibodies recognizing different domains of the channel, specific TRPV1 blockers and an activator, all in one economical package!

For research purposes only, not for human use
Compounds
Product NameCat #Size
Antibodies
Anti-TRPV1 (VR1) Antibody
ACC-030 1 x 0.2 ml
Anti-Rat TRPV1 (VR1) (extracellular) Antibody
ACC-029 1 x 0.2 ml
Activators/Agonists
Capsaicin
C-125 1 x 250 mg
Blockers/Antagonists
AMG 9810
A-180 1 x 10 mg
SB-366791
S-180 1 x 25 mg
Scientific Background
    • TRPV1 (also named VR1, capsaicin receptor and vanilloid receptor) is a member of the transient receptor potential (TRP) channel family, which includes TRPCTRPMTRPATRPPTRPML and the TRPV subfamilies. The TRPV subfamily consists of six members named, TRPV1-6. The TRPV1 channel is a vanilloid gated, nonselective cation channel.

      The channel has sequence homology to the TRP family, and shares a similar predicted structure of six transmembrane domain (TM) with a pore loop between TM5 and TM6.1 TRPV1 is expressed predominantly in nociceptors and in sensory neurons.2,3

      TRPV1 has many activators among them heat, protons, vanilloids like capsaicinresiniferatoxin (RTX), and lipids. This channel is associated with tissue injury and inflammation.5,6

      1. Gunthorpe, M.Jet al. (2002) Trends Pharmacol. Sci. 23, 183.
      2. Cesare, Pet al. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 7658.
      3. Kim, J. et al. (2003) Nature 424, 81.
      4. Ahern, G. Pet al. (2003) J. Biol. Chem. 278, 30429.
      5. Ross, R.Aet al. (2003) Br. J. Pharmacol. 140, 790.
      6. Tominaga, Met al. (1998) Neuron 21, 531.
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