TRPV1 Channel Premium Research Pack

All You Need for TRPV1 Channel Research
  • Lyophilized Powder
  • Antigen Incl.
  • Bioassay Tested
  • Shipped at Room Temp.
Cat #: ESP-300
Sizes: 9 Vials
Last update: 15/11/2018

Alomone Labs is pleased to offer the TRPV1 Channel Premium Research Pack (#ESP-300). The Research Pack contains all you need for TRPV1 research: Antibodies recognizing different domains of the channel, specific TRPV1 blockers and activators, all in one economical package!

For research purposes only, not for human use
Compounds
Product NameCat #Size
Anti-TRPV1 (VR1) Antibody
ACC-030 1 x 0.2 ml
Guinea pig Anti-TRPV1 (VR1) Antibody
AGP-118 1 x 0.2 ml
Anti-Rat TRPV1 (VR1) (extracellular) Antibody
ACC-029 1 x 0.2 ml
A-889425
A-195 1 x 10 mg
Capsaicin
C-125 1 x 250 mg
SB-366791
S-180 1 x 25 mg
Note A Guinea pig polyclonal antibody (#AGP-118) is included in this Research Pack. Please take into account when reacting with a secondary antibody.
Scientific Background
Scientific Background

TRPV1 (also named VR1, capsaicin receptor and vanilloid receptor) is a member of the transient receptor potential (TRP) channel family, which includes TRPCTRPMTRPATRPPTRPML and the TRPV subfamilies. The TRPV subfamily consists of six members named, TRPV1-6. The TRPV1 channel is a vanilloid gated, nonselective cation channel.

The channel has sequence homology to the TRP family, and shares a similar predicted structure of six transmembrane domain (TM) with a pore loop between TM5 and TM6.1 TRPV1 is expressed predominantly in nociceptors and in sensory neurons.2,3

TRPV1 has many activators among them heat, protons, vanilloids like capsaicin, resiniferatoxin (RTX), and lipids. This channel is associated with tissue injury and inflammation.5,6

References
  1. Gunthorpe, M.Jet al. (2002) Trends Pharmacol. Sci. 23, 183.
  2. Cesare, Pet al. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 7658.
  3. Kim, J. et al. (2003) Nature 424, 81.
  4. Ahern, G. Pet al. (2003) J. Biol. Chem. 278, 30429.
  5. Ross, R.Aet al. (2003) Br. J. Pharmacol. 140, 790.
  6. Tominaga, Met al. (1998) Neuron 21, 531.
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