- Peptide (C)RATDYLQASAITRIPS, corresponding to amino acid residues 213-228 of mouse CaVγ2 (Accession O88602). Intracellular, C-terminus.
- Rat brain membranes (1:200).
- Western blot analysis of rat brain membranes:1. Anti-Stargazin Antibody (#ACC-012), (1:200).
2. Anti-Stargazin Antibody, preincubated with Stargazin Blocking Peptide (#BLP-CC012).
- Rat spinal cord culture (1:200) (Krishnamurthy, K. et al. (2013) Brain Res. 1529, 143.).
The γ subunit protein is an auxiliary subunit of the CaV (voltage-dependent calcium) channel multimer complex. γ1 was first identified in skeletal muscle as a part of the proteins complex purified as the DHP receptor. Eight γ subunit isoforms were identified in mammalian genomes and they share some sequence as well as structure homology.1 γ subunit contains four transmembrane helices, with intracellular N- and C- termini. Usually their association with the pore-forming α1 subunit results in reduced current amplitude.
CaVγ2 is also known as Stargazin, and interacts and regulates the activity and trafficking of AMPA glutamate receptors.2