- Peptide (C)KQAAPHLKAEVGNS, corresponding to amino acid residues 417-430 of human TRPV2 (Accession Q9Y5S1). 1st extracellular loop.
- Western blot analysis of human HMC3 microglial (lanes 1 and 5), Jurkat T-cell leukemia (lanes 2 and 6), HepG2 liver hepatoma (lanes 3 and 7) and chronic myelogenous K562 leukemia (lanes 4 and 8) cell lysates:1-4. Anti-Human TRPV2 (VRL1) (extracellular) Antibody (#ACC-139), (1:200).
5-8. Anti-Human TRPV2 (VRL1) (extracellular) Antibody, preincubated with Human TRPV2/VRL1 (extracellular) Blocking Peptide (#BLP-CC139).
- Montell, C. et al. (2002) Mol. Cell 9, 229.
- Clapham, D.E. (2003) Nature 426, 517.
- Moran, M.M. et al. (2004) Curr. Opin. Neurobiol. 14, 362.
- Clapham, D.E. et al. (2003) Pharmacol. Rev. 55, 591.
- Gunthorpe, M.J. et al. (2002) Trends Pharmacol. Sci. 23, 183.
- Tominaga, M. and Caterina, M.J. et al. (2004) J. Neurobiol. 61, 3.
- Voets, T. et al. (2004) Nature 430, 748.
- Pedersen, S.F. et al. (2005) Cell Calcium 38, 233.
- Muraki, K. et al. (2003) Circ. Res. 93, 829.
- Shimosato, G. et al. (2005) Pain 119, 225.
- Saunders, C.I. et al. (2007) Mol. Immunol. 44, 1429.
- Caterina, M.J. et al. (1999) Nature 398, 436.
TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells.1 The TRP channels have six putative transmembrane domains (TM) with a pore domain between the fifth and the sixth TM, and all assemble as tetramers. Both the N- and the C-termini of all TRPs are intracellular3.
According to IUPHAR, the TRP family is comprised of numerous subfamilies on the basis of sequence homology; TRPC, TRPM, TRPV, TRPA, TRPML, and TRPP1-4. The TRPV subfamily consists of six members, TRPV1-65.
Four members of the TRPV family have been described as thermosensitive ion channels (TRPV1 to TRPV4). Each channel exhibits distinct thermal activation thresholds ranging from noxious cold (<17°C) to noxious heat (>52°C) 6,7. Although it shares around 50% homology with TRPV1, TRPV2 is not activated by capsaicin nor by protons. It has a high temperature threshold of ~52°C and is considered to play an essential role in the perception of high-intensity noxious heat stimulation8-10. TRPV2 is also considered to be a stretch-activated channel and to play a role in skeletal and cardiac muscle degeneration and pain pathway8. The TRPV2 channel is expressed in DRG neurons, different brain regions and non-neuronal tissues such as the spleen, lung and intestine and in components of the immune system5,11,12.
Application key:
Species reactivity key:
Anti-Human TRPV2 (VRL1) (extracellular) Antibody (#ACC-139) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot analysis. It has been designed to recognize TRPV2 from human samples only. It will not recognize the protein from rat or mouse samples.
Applications
Citations
Specifications
Scientific Background
Related Products
- Anti-TRPV2 (VRL1) Antibody (#ACC-032). This antibody recognizes a different epitope and thus can also be used as a control for detecting TRPV2. It does not however recognize the human isoform.
- Anti-TRPV2 (VRL1) (extracellular) Antibody (#ACC-039). This antibody recognizes a different epitope and thus can also be used as a control for detecting TRPV2. It does not however recognize the human isoform.
- Guinea pig Anti-TRPV2 (VRL1) (extracellular) Antibody (#ACC-039-GP) is raised in guinea pig and can be used in multiplex staining studies in conjunction with any of our antibodies raised in rabbit. This antibody has been raised against the same epitope as #ACC-039. It does not however recognize the human isoform.
- Anti-TRPV2 (VRL1) (extracellular)-FITC Antibody (#ACC-039-F). This FITC-conjugated antibody can be used to detect TRPV2 in live cell flow cytometry. It does not however recognize the human isoform.
- Anti-TRPV2 (VRL1) (extracellular) Antibody (#ACC-039). This antibody recognizes an extracellular epitope and can be used to detect TRPV2 in live cells. It does not however recognize the human isoform.
Antibodies
- Anti-Rat TRPV1 (VR1) (extracellular) Antibody (#ACC-029)
- Anti-TRPV1 (VR1) Antibody (#ACC-030)
- Anti-TRPV3 (extracellular) Antibody (#ACC-033)
- Anti-TRPV4 (extracellular) Antibody (#ACC-124)
- Anti-TRPV4 Antibody (#ACC-034)
- Anti-TRPV5 Antibody (#ACC-035)
- Anti-TRPV6 Antibody (#ACC-036)
- Guinea pig Anti-TRPV1 (VR1) Antibody (#ACC-030-GP (formerly AGP-118))
- Guinea pig Anti-TRPV4 Antibody (#ACC-034-GP (formerly AGP-147))
Explorer kits & Research packs
Need Help With This Product?
Our reagent specialists are here to help you find the best product for your application. Please call or email us and we will be happy to help you find the right product for the job.
Call us at
+972 2587 2202 or Email Us