- Peptide (CD)TINGTWEGDELGYK, corresponding to amino acid residues 11-24 of rat P2RY2 (Accession P41232). Extracellular, C-terminus.
- Cell surface detection of P2RY2 in live intact mouse J774 macrophage cells:___ Cells.
___ Cells + rabbit IgG isotype control-FITC.
___ Cells + Anti-P2Y2 Receptor (extracellular)-FITC Antibody (#APR-102-F), (2.5 µg). - Cell surface detection of P2RY2 in live intact human THP-1 monocytic leukemia cells:___ Cells.
___ Cells + rabbit IgG isotype control-FITC.
___ Cells + Anti-P2Y2 Receptor (extracellular)-FITC Antibody (#APR-102-F), (5 µg).
- Wang, L. et al. (2002) J. Cardiovas. Pharmacol. 40, 841.
- Queiroz, G. et al. (2003) J. Pharmacol. Exp. Ther. 307, 809.
- Ralevic, V. and Burnstock, G. (1998) Pharmacol. Rev. 50, 413.
- Abbracchio, M.P. et al. (2003) Trends Pharmacol. Sci. 24, 52.
- Di Virgilio, F. et al. (2001) Blood 97, 587.
- Yerxa, B.R. et al. (2002) J. Pharmacol. Exp. Ther. 302, 871.
P2Y receptors belong to the G-protein coupled receptor superfamily. P2Y receptors mediate the actions of the extracellular nucleotides (ATP, ADP, UTP and UDP) and regulate several physiological responses, among them, cardiac function, platelet aggregation and SMC proliferation1.
The mammalian P2Y family currently includes eight functional receptors; P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and the UDP-glucose receptor, now renamed P2Y142-4.
The P2Y2 receptor is abundantly expressed in the apical membranes of several epithelial tissues including airway5. It has become a leading target for the treatment of cystic fibrosis. Activation of P2RY2 increases Cl- efflux and mucociliary clearance, effects that might relieve symptoms of cystic fibrosis. P2Y2 agonist therapy is tested in an attempt to bypass the dysfunctioning CFTR channel. Several P2Y2 receptor agonists, especially INS37217, being evaluated as possible targets for the treatment of cystic fibrosis6.
Application key:
Species reactivity key:
Anti-P2Y2 Receptor (extracellular) Antibody (#APR-102) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, indirect live cell flow cytometry, and immunohistochemistry applications. It has been designed to recognize P2RY2 from rat, mouse, and human samples.
Anti-P2Y2 Receptor (extracellular)–FITC Antibody (#APR-102-F) is directly conjugated to fluorescein isothiocyanate (FITC). This labeled antibody can be used in immunofluorescent applications such as direct flow cytometry using live cells.
Applications
Citations
Specifications
Scientific Background
Related Products
- Anti-P2Y2 Receptor (extracellular) Antibody (#APR-102), (for western blot analysis).
- Anti-P2Y2 Receptor Antibody (#APR-010). This antibody recognizes a different epitope and can be used as a control for detecting P2Y2 receptor.
- Anti-P2Y2 Receptor (extracellular) Antibody (#APR-102). This antibody can be used to detect P2Y2 in live cell flow cytometry.
Antibodies
- Anti-P2Y1 Receptor (extracellular) Antibody (#APR-021)
- Anti-P2Y1 Receptor (extracellular)-ATTO Fluor-488 Antibody (#APR-021-AG)
- Anti-P2Y4 Receptor Antibody (#APR-006)
- Anti-P2Y6 Receptor (extracellular) Antibody (#APR-106)
- Anti-Human P2Y11 Receptor Antibody (#APR-015)
- Anti-P2Y12 Receptor (extracellular) Antibody (#APR-020)
- Anti-P2Y12 Receptor (extracellular)-FITC Antibody (#APR-020-F)
- Anti-P2X7 Receptor (extracellular)-PE Antibody (#APR-008-PE)
- Anti-P2Y6 Receptor (extracellular)-FITC Antibody (#APR-106-F)
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