Purinergic Receptor Antibodies for Pain Research Explorer Kit

A Screening Package of Purinergic Receptor Antibodies for Pain Research Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
Cat #: AK-400
Sizes: 26 Vials
Last update: 24/04/2019

Alomone Labs is pleased to offer the Purinergic Receptor Antibodies for Pain Research Explorer Kit (#AK-400). The Explorer Kit contains purinergic receptors antibodies for pain research, ideal for screening purposes.

For research purposes only, not for human use
Compounds
Scientific Background
    • P2X receptors comprise a seven-member family (P2X1-7) of extracellular ATP-gated cation channels of widespread expression including somatic and nervous tissues. These receptors are implicated in a variety of neurological, inflammatory and cardiovascular diseases1. P2X receptors consist of two transmembrane subunits with a large extracellular domain, which shows conserved cysteine residues in all members of the family. P2X3 was the focus of pain pathways research due to its selective expression in nociceptive neurons. Interestingly, expression of P2X3 is species specific. While the rat form seems to be sensory neuron specific in mice and human there is a broader pattern of expression, with some evidence for expression in cardiac muscle and motor neurons. Immunocytochemistry studies have indicated an upregulation of P2X3 receptors in both DRG and dorsal horn neurons following neuropathic injury.

      ATP and thus P2X receptors play a significant role in pain pathways. αβmeATP (A P2X agonist) intrathecal administration produces a dose-dependent thermal hyperalgesic response which is blocked with P2X antagonists PPADS and TNP-ATP. ATP agonists do not cause a similar response in P2X1 receptors, suggesting it is not involved in this effect. Animals injected with P2X agonists exhibit overt nociceptive behaviour such as hindpaw lifting and licking2. P2X receptors have also been implicated as having a major role in visceral sensory function and have been put forward as potential therapeutic targets for visceral pain such as IBD and IBS. ATP released from epithelium lining cells upon distention of hollow organs acts on the P2X receptors which relay the information to the CNS and subsequently cause pain3.

      Other purinergic receptors involved in pain include members of P2Y receptors and Adenosine receptors.

      1. Hausmann, R. et al. (2015) Curr. Med. Chem22, 799.
      2. Ding, Y. et al. (2000) J. Auton. Nerv. Syst. 81, 289.
      3. Deiteren, A et al. (2015) PLoS ONE 10, e0123810.
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