This product is freeze dried. All water molecules have been removed.
The activity of this product has been verified and approved by our professional team.
Boehlen, A. et al. (2013) Br. J. Pharmacol. 168, 1182.
KV7 or KCNQs are voltage-gated K+ channels. These channels are mainly responsible for the cardiac and auditory IK currents and the neuronal M-current but can be found in other tissues as well. Voltage-gated K+ channels are tetramers of α-subunits, which surround a K+-selective pore1. The different five KCNQ subtypes have distinct assembly preferences encoded by a C-terminal cytoplasmic assembly domain, the A-domain tail. This domain is a self-assembling, parallel, four-stranded coiled coil2.
ICA-110381 is a synthetic opener of KCNQ channels with an effective concentration of 0.1μM-10μM. In hippocampal CA1 cells, ICA-110381 reduces cell membrane excitability caused by hyperpolarization and decreases membrane resistance. It exhibits strong anticonvulsant properties by acting mainly on the KCNQ2 subunit of the KV7 channel and reduces seizure severity and frequency3.
ICA-110381 (#I-160) is a highly pure, synthetic, and biologically active compound.
- Anti-KCNQ2 Antibody (#APC-050)
- Anti-KCNQ3 Antibody (#APC-051)
- Anti-KCNQ1 Antibody (#APC-022)
- Anti-KCNQ5 Antibody (#APC-155)
- Anti-KCNQ4 Antibody (#APC-164)
- KCNQ (KV7) Channel Antibody Explorer Kit (#AK-221)
- Celecoxib (#C-190)
- Flupirtine Maleate (#F-150)
- ICA-27243 (#I-130)
- Linopirdine dihydrochloride (#L-156)
- Retigabine dihydrochloride (#R-101)
- XE991 (#X-100)
- XE991 dihydrochloride (#X-101)
- 2,5-dimethylcelecoxib (#D-150)
- SsTx Toxin (#STS-700)