Pacemaker Cell Marker Antibody Explorer Kit

A Screening Package of Antibodies to SAN Expressing Proteins Economically Priced
  • New
  • Lyophilized Powder
  • Antigen Incl.
  • Shipped at Room Temp.
Cat #: AK-620
Sizes: 22 Vials
Last update: 06/08/2018

Pacemaker Cell Marker Antibody Explorer Kit (#AK-620) is a budget friendly screening package.

For research purposes only, not for human use
Compounds
Product NameCat #Size
Guinea pig Anti-HCN1 Antibody
AGP-203 1 x 50 µl
Guinea pig Anti-HCN4 Antibody
AGP-004 1 x 50 µl
Anti-Connexin-32 Antibody
ACC-211 1 x 50 µl
Anti-Connexin-45 Antibody
ACC-207 1 x 50 µl
Guinea pig Anti-CaV1.3 Antibody
AGP-061 1 x 50 µl
Anti-CaV3.1 Antibody
ACC-021 1 x 50 µl
Anti-CaV3.2 Antibody
ACC-025 1 x 50 µl
Anti-Ryanodine Receptor 2 Antibody
ARR-002 1 x 50 µl
Anti-KCNQ1 Antibody
APC-022 1 x 50 µl
Anti-KV11.1 (HERG) Antibody
APC-062 1 x 50 µl
Anti-Na+/Ca2+ Exchanger 1 (NCX-1) Antibody
ANX-011 1 x 50 µl
Scientific Background
Scientific Background

The intrinsic pacemaker system is responsible to initiate and to control the rhythmic contraction of the heart. Pacemaker cells are located in the sinoatrial node (SAN) in mammals and are considered to be the heart’s primary pacemaker cells. Sinoatrial nodal cells generate spontaneous action potentials (APs) responsible for controlling cardiac rate.  Studies show a number of cardiac diseases associated with changes in heart rate and specifically with the failing of pacemaker cell mechanisms such as in sick sinus syndrome and heart failure. Additional cardiac diseases occur because of the presence of mutations in pacemaker cell ion channels1,3.

The sinoatrial node cell function is regulated by two main signaling cascades: the autonomic nervous system which stimulates membrane receptors that activate adrenergic or inactivate cholinergic adenylyl cyclase and the internal coupled-clock system.

Acceleration of action potential causes heart rate to increase by a mechanism that relies on an intracellular Ca2+ release and uptake process that is coupled to inward cell membrane ionic currents.  In response to β adrenergic receptor agonist stimulation, cardiac pacemaker cells can accelerate heart rate as part of the physiological fight-or-flight response1,2.

References
  1. Behar, J. et al. (2016) Front. Physiol. 7, 419.
  2. Wu, Y. et al. (2016) Circ. Arrhythm. Electrophysiol. 9, e003180.
  3. Burkhard, S. et al. (2017) J. Cardiovasc. Dev. Dis. 4, 2.
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