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QO-40

An Opener of KCNQ Channels

Cat #: Q-265
Lyophilized Powder yes
  • Bioassay Tested
    • Source Synthetic
    MW: 377.8
    Purity: >99%
    Effective concentration 1-100 µM.
    Structure
    Chemical name 5-(chloromethyl)-3-(naphthalen-1-yl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one.
    Molecular formula C18H11ClF3N3O.
    Activity QO-40 is a KCNQ channel opener with EC50 of ~7 µM on cloned channels and on native M-current in DRG neurons1.
    References-Activity
    1. Jia, C. et al. (2011) Pharmacology 87, 297.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs QO-40 enhances KCNQ2/KCNQ3 heteromeric channels expressed in Xenopus oocytes. 
      Alomone Labs QO-40 enhances KCNQ2/KCNQ3 heteromeric channels expressed in Xenopus oocytes. 
      A. Time course of KCNQ2/KCNQ3 current enhancement by 40 and 100 µM QO-40 (#Q-265). Currents were elicited by application of voltage step from a holding potential of -100 mV to -60 mV (800 msec). B. Superimposed example traces of current responses before and during perfusion of 40 and 100 µM QO-40, as indicated.
    References - Scientific background
    1. Jia, C. et al. (2011) Pharmacology 87, 297.
    2. Zhang. F. et al. (2013) Br. J. Pharmacol. 168, 1030.
    3. Blom, S.M. et al. (2014) PLoS One 9, e100209.
    Scientific background

    QO-40 potently enhances KCNQ channels. It has the ability to decrease the firing of overactive neurons. In medicine, this compound is being used for the treatment of epilepsy and neuropathic pain. In a study conducted on Chinese hamster ovary cells, QO-40 managed to shift the half-maximal activation voltage in the hyperpolarizing direction in a concentration-dependent manner1. QO-40 demonstrates EC50 value of approximately 7 µM on cloned channels and on native M-currents expressed in dorsal root ganglia neurons1.

    The voltage-gated M-type potassium channels of the KV7 family encoded by the KCNQ gene family, plays an important role in controlling neuronal excitability. KCNQ gene family seems to affect migraine and neuropathic pain. Several recent studies have shown that genetic mutations in KCNQ channel can lead to neonatal epilepsy in humans and mice.

    KCNQ channels are expressed in the sensory system including the trigeminal ganglion neurons and dorsal root ganglion2,3.

    Target KCNQ channels
    Lyophilized Powder
    Last update: 25/07/2021

    QO-40 (#Q-265) is a highly pure, synthetic, and biologically active compound.

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    For research purposes only, not for human use
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