KCNQ (KV7) Channel Modulator Explorer Kit

A Screening Package of KCNQ (KV7) Channel Modulators Economically Priced
  • Lyophilized Powder
  • Bioassay Tested
  • Shipped at Room Temp.
Cat #: EK-131
Sizes: 12 Vials
Last update: 27/11/2018

Alomone Labs is pleased to offer the KCNQ (KV7) Channel Modulator Explorer Kit (#EK-131). The Explorer Kit contains KCNQ channel blockers and activators, ideal for screening purposes.

For research purposes only, not for human use
Product Name Cat # Size
D-150 1 x 5 mg
C-190 1 x 100 mg
D-180 1 x 1 g
Flupirtine Maleate
F-150 1 x 5 mg
I-130 1 x 5 mg
I-160 1 x 5 mg
Linopirdine dihydrochloride
L-156 1 x 5 mg
Meclofenamic acid
M-210 1 x 5 mg
N-115 1 x 10 mg
Q-265 1 x 5 mg
Retigabine dihydrochloride
R-101 1 x 10 mg
XE991 dihydrochloride
X-101 1 x 5 mg
Scientific Background

KCNQ genes encode members of the KV7 K+ channels. Structurally, the KCNQ family belongs to the six transmembrane domain category of K+ channels. Five members belong to this family (KCNQ1-KCNQ5) of which KCNQ2 to KCNQ5 are expressed in the nervous system1-3. KCNQ5 is also expressed in visceral smooth muscle4 and skeletal muscle5.

These channels form subunits of the low threshold voltage-gated K+ channel. KCNQ2 and KCNQ3 mostly form heteromers to form the M current. KCNQ5 is known to contribute to this current1.

  1. Brown, D.A. and Passmore, G.M. (2009) Br. J. Pharmacol. 156, 1185.
  2. Jensen, H.S. et al. (2005) Brain Res. Mol. Brain Res. 139, 52.
  3. Robbins, J. (2001) Pharmacol. Ther. 90, 1.
  4. Jentsch, T.J. (2000) Nat. Rev. Neurosci. 1, 21.
  5. Lerche, C. et al. (2000) J. Biol. Chem. 275, 22395.
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