TTA-P2 (S-enantiomer)

A Blocker of T-Type CaV Channels
    Cat #: T-210
  • Lyophilized Powder
  • Bioassay Tested
  • Source Synthetic
    MW: 431
    Purity: >99%
    Form Lyophilized powder.
    Effective concentration 0.05-10 µM.
      • TTA-P2 (S-enantiomer)
    Chemical name (S)-3,5-Dichloro-N-((1-((2,2-dimethyltetrahydro-2H-pyran-4-yl)methyl)-4-fluoropiperidin-4-yl)methyl)benzamide.
    Molecular formula C21H29Cl2FN2O2.
    CAS No.: 1072018-68-8.
    PubChem CID 24893979
    Activity TTA-P2 blocks T-type currents in DRGs with IC50 of 100 nM and 22 nM in thalamocortical and reticular neurons1,2.
      • Choe, W. et al. (2011) Mol. Pharmacol. 80, 900.
      • Dreyfus, F.M. et al. (2010) J. Neurosci. 30, 99.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 50 mM in DMSO. Centrifuge all product preparations before use (10,000 x g for 1 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
      • TTA-P2 (S-enantiomer)
        Alomone Labs TTA-P2 (S-enantiomer) blocks T-type CaV channels expressed in Xenopus oocytes.
        A. Time course of CaV3.2 peak current amplitude, elicited by 100 ms voltage step from holding potential of -100 mV to -30 mV, delivered every 10 seconds. Application of 5 µM TTA-P2 (S-enantiomer) (#T-210) inhibits the CaV3.2 current in a reversible manner (indicated by the horizontal bar). B. Representative current traces before and during application of 5 µM TTA-P2 as indicated.
    References - Scientific background
    • 1. Dreyfus, F.M. et al. (2010) J. Neurosci. 30, 99.
    • 2. Choe, W. et al. (2011) Mol. Pharmacol. 80, 900.
      • TTA-P2 is a novel, potent and selective T-type CaV channel blocker. In thalamocortical and reticular neurons, it blocks T-type currents with an IC50 of 22 nM without affecting high voltage Ca2+ channels1. In rat DRGs, it blocks T-type currents with an IC50 of 100 nM and stabilizes the channel in the inactive state2.

        TTA-P2 has the potential of acting as an antinociceptive agent2.

    Target CaV3 channels
    Last update: 23/09/2019

    TTA-P2 (S-enantiomer) (#T-210) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use