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TTA-P2 (S-enantiomer)

A Blocker of T-Type CaV Channels

Cat #: T-210
Lyophilized Powder yes
  • Bioassay Tested
  • Source Synthetic
    MW: 431
    Purity: >99%
    Form Lyophilized powder.
    Effective concentration 0.05-10 µM.
    Structure
    Chemical name (S)-3,5-Dichloro-N-((1-((2,2-dimethyltetrahydro-2H-pyran-4-yl)methyl)-4-fluoropiperidin-4-yl)methyl)benzamide.
    Molecular formula C21H29Cl2FN2O2.
    CAS No.: 1072018-68-8
    PubChem CID 24893979
    Activity TTA-P2 blocks T-type currents in DRGs with IC50 of 100 nM and 22 nM in thalamocortical and reticular neurons1,2.
    References-Activity
    1. Choe, W. et al. (2011) Mol. Pharmacol. 80, 900.
    2. Dreyfus, F.M. et al. (2010) J. Neurosci. 30, 99.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 50 mM in DMSO. Centrifuge all product preparations before use (10,000 x g for 1 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs TTA-P2 (S-enantiomer) blocks T-type CaV channels expressed in Xenopus oocytes.
      Alomone Labs TTA-P2 (S-enantiomer) blocks T-type CaV channels expressed in Xenopus oocytes.
      A. Time course of CaV3.2 peak current amplitude, elicited by 100 ms voltage step from holding potential of -100 mV to -30 mV, delivered every 10 seconds. Application of 5 µM TTA-P2 (S-enantiomer) (#T-210) inhibits the CaV3.2 current in a reversible manner (indicated by the horizontal bar). B. Representative current traces before and during application of 5 µM TTA-P2 as indicated.
    References - Scientific background
    1. Dreyfus, F.M. et al. (2010) J. Neurosci. 30, 99.
    2. Choe, W. et al. (2011) Mol. Pharmacol. 80, 900.
    Scientific background

    TTA-P2 is a novel, potent and selective T-type CaV channel blocker. In thalamocortical and reticular neurons, it blocks T-type currents with an IC50 of 22 nM without affecting high voltage Ca2+ channels1. In rat DRGs, it blocks T-type currents with an IC50 of 100 nM and stabilizes the channel in the inactive state2.

    TTA-P2 has the potential of acting as an antinociceptive agent2.

    Target CaV3 channels
    Last update: 12/08/2021

    TTA-P2 (S-enantiomer) (#T-210) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
    Shipping and Ordering information