- Peptide MDEEEDGAGAEESGQPRSFTQL(C), corresponding to amino acid residues 1-22 of rat CACNA1G (Accession O54898). Intracellular, N-terminus.
- Expression of CACNA1G in rat and mouse cerebellumImmunohistochemical staining of mouse (A) and rat (B) cerebellum using Anti-CACNA1G (CaV3.1)-ATTO Fluor-594 Antibody (#ACC-021-AR). A, B. CACNA1G staining (red) appears in Purkinje neurons (arrow) and in the molecular layer (Mol). Nuclei were stained using DAPI as the counterstain (Blue).
Voltage-dependent Ca2+ channels provide a pathway for rapid influx of Ca2+ into cells, which plays a crucial role in both electrical and metabolic signaling.1
T-type currents are transduced via channel proteins encoded by three genes that compose a subfamily within the CaV channel family.2-3
The activity of T-type channels contributes to several known physiological and pathophysiological phenomena including burst firing in neurons, pacemaking activity in the heart and secretion from endocrine tissues.2 There are three cloned T-type channel isoforms.
CACNA1G and CACNA1H are also expressed in the kidney, but little is known about their physiological role there.
Species reactivity key:
Anti-CACNA1G (CaV3.1) Antibody (#ACC-021) is a highly specific antibody directed against an epitope of the rat CaV3.1 channel. The antibody can be used in western blot, immunocytochemistry, and immunohistochemistry applications. It has been designed to recognize CACNA1G from human, rat, and mouse samples.
Anti-CACNA1G (CaV3.1)-ATTO Fluor-594 Antibody (#ACC-021-AR) is directly labeled with ATTO-594 fluorescent dye. ATTO dyes are characterized by strong absorption (high extinction coefficient), high fluorescence quantum yield, and high photo-stability. The ATTO-594 fluorescent label belongs to the class of Rhodamine dyes and can be used with fluorescent equipment typically optimized to detect Texas Red and Alexa-594. Anti-CACNA1G (CaV3.1)-ATTO Fluor-594 Antibody is ideal for multiplex staining studies.