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Lyophilized Powder Lyophilized PowderThis product is freeze dried. All water molecules have been removed.
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Bioassay Tested Bioassay TestedThis antibody has undergone quality control and has been approved by our professional team.
Alomone Labs is pleased to offer the TTX-Resistant NaV Channel Blocker Explorer Kit (#EK-106). This Explorer Kit includes both classical and novel NaV blockers, ideal for screening purposes.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
A-803467 | A-105 | 1 x 10 mg |
Ambroxol hydrochloride | A-145 | 1 x 1 g |
Jingzhaotoxin-III | STJ-200 | 1 x 50 µg |
Jingzhaotoxin XI | STJ-400 | 1 x 0.1 mg |
Jingzhaotoxin-XII | STJ-100 | 1 x 50 µg |
Ralfinamide mesylate | R-105 | 1 x 5 mg |
Ranolazine | R-110 | 1 x 10 mg |
Tolperisone hydrochloride | T-115 | 1 x 25 mg |
Scientific Background
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Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability.1 NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions.
To date, nine NaV α subunits have been cloned and named NaV1.1-NaV1.9.4-5 The NaV channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9).2-3 Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific.
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