-
Lyophilized Powder Lyophilized PowderThis product is freeze dried. All water molecules have been removed.
-
Bioassay Tested Bioassay TestedThis antibody has undergone quality control and has been approved by our professional team.
Alomone Labs is pleased to offer the TTX-Resistant NaV Channel Blocker Explorer Kit (#EK-106). This Explorer Kit includes both classical and novel NaV blockers, ideal for screening purposes.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
A-803467 | A-105 | 1 x 10 mg |
Ambroxol hydrochloride | A-145 | 1 x 1 g |
Jingzhaotoxin-III | STJ-200 | 1 x 50 µg |
Jingzhaotoxin XI | STJ-400 | 1 x 0.1 mg |
Jingzhaotoxin-XII | STJ-100 | 1 x 50 µg |
Ralfinamide mesylate | R-105 | 1 x 5 mg |
Ranolazine | R-110 | 1 x 10 mg |
Tolperisone hydrochloride | T-115 | 1 x 25 mg |
Scientific Background
-
Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability.1 NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions.
To date, nine NaV α subunits have been cloned and named NaV1.1-NaV1.9.4-5 The NaV channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9).2-3 Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific.
Need Help With This Product?
Our reagent specialists are to help you find the best product for your application. Please Call or Email us and we will be happy to help you find the right product for the job.
Call us at
+972 2587 2202 or Email Us
