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TTX-Resistant NaV Channel Blocker Explorer Kit

A Screening Package of TTX-Resistant NaV Channel Blockers Economically Priced
  • Lyophilized Powder
  • Bioassay Tested
Cat #: EK-106
Sizes: 8 Vials
Last update: 24/04/2019

Alomone Labs is pleased to offer the TTX-Resistant NaV Channel Blocker Explorer Kit (#EK-106). This Explorer Kit includes both classical and novel NaV blockers, ideal for screening purposes.

For research purposes only, not for human use
Compounds
Product Name Cat # Size
A-803467
 		A-105 1 x 10 mg
Ambroxol hydrochloride
 		A-145 1 x 1 g
Jingzhaotoxin-III
 		STJ-200 1 x 50 µg
Jingzhaotoxin XI
 		STJ-400 1 x 0.1 mg
Jingzhaotoxin-XII
 		STJ-100 1 x 50 µg
Ralfinamide mesylate
 		R-105 1 x 5 mg
Ranolazine
 		R-110 1 x 10 mg
Tolperisone hydrochloride
 		T-115 1 x 25 mg
References
Scientific Background

Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability.1 NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions.

To date, nine NaV α subunits have been cloned and named NaV1.1-NaV1.9.4-5  The NaV channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9).2-3 Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific.
References
  1. Lai, J. et al. (2003) Curr. Opin. Neurobiol 13, 291.
  2. Fang, X. et al. (2002) J. Neurosci. 22, 7425.
  3. Wu, L. et al. (2002) NeuroReport 13, 2547.
  4. Baker, M.D. et al. (2001) Trends Pharmacol. Sci. 22, 27.
  5. Fjell, J. et al. (2000) NeuroReport 11, 199.
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