AMG-9090 is a small synthetic molecule that acts as a TRPA1 channel blocker. AMG-9090 was shown to inhibit intracellular calcium increase mediated by human TRPA1 channels in Chinese hamster ovary cells with IC₅₀ values of 21 nM¹. The compound also possesses inhibitory effects on human TRPM8 and TRPV1 channels^1,2.

TRPA1 channels are non-selective cation channels expressed in the small neurons of the dorsal root and trigeminal ganglia. They play an important role in models of inflammatory and neuropathic pain and have the ability to detect pungent or irritant compounds.

Studies have shown that blockade of TRPA1 channels may help in migraine attack and can be used as a possible new target for its treatment. Also, evidence shows that TRPA1 blockers could serve as novel therapeutic strategies for chemotherapeutic induced peripheral neuropathy^1,3.