- Peptide MDEEEDGAGAEESGQPRSFTQL(C), corresponding to amino acid residues 1-22 of rat CACNA1G (Accession O54898). Intracellular, N-terminus.
- Rat and mouse cerebellum.
- Expression of CACNA1G in rat and mouse cerebellumImmunohistochemical staining of mouse (A) and rat (B) cerebellum using Anti-CACNA1G (CaV3.1)-ATTO Fluor-594 Antibody (#ACC-021-AR). A, B. CACNA1G staining (red) appears in Purkinje neurons (arrow) and in the molecular layer (Mol). Nuclei were stained using DAPI as the counterstain (Blue).
Voltage-dependent Ca2+ channels provide a pathway for rapid influx of Ca2+ into cells, which plays a crucial role in both electrical and metabolic signaling.1
T-type currents are transduced via channel proteins encoded by three genes that compose a subfamily within the CaV channel family.2-3
The activity of T-type channels contributes to several known physiological and pathophysiological phenomena including burst firing in neurons, pacemaking activity in the heart and secretion from endocrine tissues.2 There are three cloned T-type channel isoforms.
CACNA1G and CACNA1H are also expressed in the kidney, but little is known about their physiological role there.