Every lot is tried & tested in a relevant biological assay.
Arg64 - Arginine amide
- Chow, C.Y. et al. (2020) ACS Pharmacol. Transl. Sci. 3, 119.
- Alomone Labs Hj2a Toxin enhances the current of NaV1.6 channels expressed in Xenopus oocytes.A. Representative time course of Hj2a Toxin (#STH-555) effect on the normalized area of NaV1.6 channel current. Membrane potential was held at -100 mV, current was elicited by a 100 ms voltage step to 0 mV every 10 sec, and was significantly enhanced by the application of 0.5 μM Hj2a Toxin (green). B. Superimposed traces of NaV1.6 current after application of control (black) and of 0.5 μM Hj2a Toxin (green), taken from the recording in A.
δ-buthitoxin-Hj2a (Hj2a) is a peptidyl toxin originally isolated from the venom of the scorpion, Hottentotta jayakari. Hj2a acts as a voltage-gated sodium (Nav) 1.1 channel activator, but it also harbors promiscuous activity towards multiple human NaV channel subtypes. Hj2a is unique in that it exhibits a dual α/β mode of action by modifying both the inactivation (α-toxin activity) and activation (β-toxin activity) properties of the NaV1.1 channel1.
NaV channels are involved in a wide array of physiological processes and play a fundamental role in normal neurological function, especially in the initiation and propagation of action potentials. In particular, the NaV1.1 channel is predominantly expressed in inhibitory interneurons of the brain and it plays a major role in regulating brain rhythms and cognitive functions. Mutations in the NaV1.1 channel were shown to be associated with Dravet syndrome (DS), a severe form of pediatric epilepsy. Selective modulators of the NaV1.1 channel can be useful therapeutics for DS treatment since they target the underlying molecular deficit. The unusual dual mode of action of Hj2a provides an alternative approach for the development of selective NaV1.1 channel modulators for the treatment of DS1,2.
Widget not in any sidebars
Hj2a Toxin (#STH-555) is a highly pure, synthetic, and biologically active peptide toxin.