Name: KCNQ (KV7) Channel Activator Explorer Kit
Brand: Alomone Labs
SKU: EK-225
Price: 284.00 USD
Availability: InStock

Overview

Cat #: EK-225

Size: 5 Vials

Form: Lyophilized

Alomone Labs is pleased to offer the KCNQ (K_V7) Channel Activator Explorer Kit (#EK-225). The Explorer Kit contains KCNQ channel activators, ideal for screening purposes.

For research purposes only, not for human use

Compounds

Product Name	Cat #	Size
2,5-dimethylcelecoxib	D-150	1 x 5 mg
ICA-110381	I-160	1 x 5 mg
ICA-27243	I-130	1 x 5 mg
NS-1643	N-115	1 x 10 mg
Retigabine dihydrochloride	R-101	1 x 10 mg

Scientific Background

KCNQ genes encode members of the K_V7 K⁺ channels. Structurally, the KCNQ family belongs to the six transmembrane domain category of K⁺ channels. Five members belong to this family (KCNQ1-KCNQ5) of which KCNQ2 to KCNQ5 are expressed in the nervous system^1-3. KCNQ5 is also expressed in visceral smooth muscle⁴ and skeletal muscle⁵.

These channels form subunits of the low threshold voltage gated K⁺ channel. KCNQ2 and KCNQ3 mostly form heteromers to form the M current. KCNQ5 is known to contribute to this current¹.

References

Brown, D.A. and Passmore, G.M. (2009) Br. J. Pharmacol. 156, 1185.
Jensen, H.S. et al. (2005) Brain Res. Mol. Brain Res. 139, 52.
Robbins, J. (2001) Pharmacol. Ther. 90, 1.
Jentsch, T.J. (2000) Nat. Rev. Neurosci. 1, 21.
Lerche, C. et al. (2000) J. Biol. Chem. 275, 22395.

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Order Summary

KCNQ (K_V7) Channel Activator Explorer Kit

Overview

Compounds

Compounds

2,5-dimethylcelecoxib

ICA-110381

ICA-27243

NS-1643

Retigabine dihydrochloride

Scientific Background

Scientific Background

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