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Lyophilized Powder Lyophilized PowderThis product is freeze dried. All water molecules have been removed.
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Bioassay Tested Bioassay TestedThis antibody has undergone quality control and has been approved by our professional team.
Alomone Labs is pleased to offer the KCNQ (KV7) Channel Activator Explorer Kit (#EK-225). The Explorer Kit contains KCNQ channel activators, ideal for screening purposes.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
Celecoxib | C-190 | 1 x 100 mg |
Diclofenac | D-180 | 1 x 1 g |
2,5-dimethylcelecoxib | D-150 | 1 x 5 mg |
Flupirtine Maleate | F-150 | 1 x 5 mg |
ICA-110381 | I-160 | 1 x 5 mg |
ICA-27243 | I-130 | 1 x 5 mg |
Meclofenamic acid | M-210 | 1 x 5 mg |
NS-1643 | N-115 | 1 x 10 mg |
Retigabine dihydrochloride | R-101 | 1 x 10 mg |
Scientific Background
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KCNQ genes encode members of the KV7 K+ channels. Structurally, the KCNQ family belongs to the six transmembrane domain category of K+ channels. Five members belong to this family (KCNQ1-KCNQ5) of which KCNQ2 to KCNQ5 are expressed in the nervous system1-3. KCNQ5 is also expressed in visceral smooth muscle4 and skeletal muscle5.
These channels form subunits of the low threshold voltage gated K+ channel. KCNQ2 and KCNQ3 mostly form heteromers to form the M current. KCNQ5 is known to contribute to this current1.
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- Brown, D.A. and Passmore, G.M. (2009) Br. J. Pharmacol. 156, 1185.
- Jensen, H.S. et al. (2005) Brain Res. Mol. Brain Res. 139, 52.
- Robbins, J. (2001) Pharmacol. Ther. 90, 1.
- Jentsch, T.J. (2000) Nat. Rev. Neurosci. 1, 21.
- Lerche, C. et al. (2000) J. Biol. Chem. 275, 22395.
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