Overview
Alomone Labs is pleased to offer the KCNQ (KV7) Channel Activator Explorer Kit (#EK-225). The Explorer Kit contains KCNQ channel activators, ideal for screening purposes.
Compounds
Product Name | Cat # | Size |
---|---|---|
2,5-dimethylcelecoxib |
D-150 | 1 x 5 mg |
ICA-110381 |
I-160 | 1 x 5 mg |
ICA-27243 |
I-130 | 1 x 5 mg |
NS-1643 |
N-115 | 1 x 10 mg |
Retigabine dihydrochloride |
R-101 | 1 x 10 mg |
Scientific Background
KCNQ genes encode members of the KV7 K+ channels. Structurally, the KCNQ family belongs to the six transmembrane domain category of K+ channels. Five members belong to this family (KCNQ1-KCNQ5) of which KCNQ2 to KCNQ5 are expressed in the nervous system1-3. KCNQ5 is also expressed in visceral smooth muscle4 and skeletal muscle5.
These channels form subunits of the low threshold voltage gated K+ channel. KCNQ2 and KCNQ3 mostly form heteromers to form the M current. KCNQ5 is known to contribute to this current1.
- Brown, D.A. and Passmore, G.M. (2009) Br. J. Pharmacol. 156, 1185.
- Jensen, H.S. et al. (2005) Brain Res. Mol. Brain Res. 139, 52.
- Robbins, J. (2001) Pharmacol. Ther. 90, 1.
- Jentsch, T.J. (2000) Nat. Rev. Neurosci. 1, 21.
- Lerche, C. et al. (2000) J. Biol. Chem. 275, 22395.
Related Products
- Anti-KCNQ1 Antibody (#APC-022)
- Guinea pig Anti-KCNQ1 Antibody (#APC-022-GP (formerly AGP-050))
- Anti-KCNQ1 (extracellular) Antibody (#APC-168)
- Anti-KCNQ2 Antibody (#APC-050)
- Guinea pig Anti-KCNQ2 Antibody (#APC-050-GP (formerly AGP-065))
- Anti-KCNQ3 Antibody (#APC-051)
- Anti-KCNQ4 Antibody (#APC-164)
- Anti-KCNQ5 Antibody (#APC-155)
- KCNQ (KV7) Channel Antibody Explorer Kit (#AK-221)
- KCNQ (KV7) Channel Modulator Explorer Kit (#EK-131)
- KCNQ (KV7) Channel Basic Research Pack (#ESB-503)
Resources
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