Every lot is tried & tested in a relevant biological assay.
Our Bioassay
- Hess, P. et al. (1984) Nature 311, 538.
- Nowycky, M.C. et al. (1985) Proc. Natl. Acad. Sci. U.S.A. 82, 2178.
- Bechem, M. and Hoffmann, H. (1993) Pflugers Arch. 424, 343.
- Triggle, D.J. and Rampe, D. (1989) Trends Pharmacol. Sci. 10, 507.
- Avdonin, V. et al. (1997) J. Gen. Physiol. 109, 169.
- Alomone Labs (±)-Bay K8644 increases L-type Ca2+ currents expressed in Xenopus oocytes.Left: I-V relation before (squares) and during (circles) bath perfusion of 5 μM (±)-Bay K8644 (#B-350). Right: An example of current response to 200 ms depolarization to +20mV (from holding potential of -100 mV) before (black) and during (pink) perfusion of (±)-Bay K8644.
- Alomone Labs (±)-Bay K8644 modulates the phosphorylation of ERK1/2 MAPK in Jurkat T cells.Cells were preincubated with or without EGTA or Nifedipine for 20 min then stimulated with (±)-Bay K8644 (#B-350) or with Ionomycin for 10 min. The cell proteins were blotted and probed with anti-phospho ERK1/2 (upper panel) or with anti-ERK1/2 (lower panel).
- Hess, P. et al. (1984) Nature 311, 538.
- Nowycky, M.C. et al. (1985) Proc. Natl. Acad. Sci. U.S.A. 82, 2178.
- Bechem, M. and Hoffmann, H. (1993) Pflugers Arch. 424, 343.
(±)-Bay K8644 is an opener of all L-type channels (CaV1 family). In the presence of this agonist, channels tend to open for longer periods causing a large increase in the channel macroscopic response.
The net activity of the racemic mix is that of the (-)-enantiomer agonistic activity.
(±)-Bay K8644 is a widely used L-type Ca2+ channel activator in various neuronal, muscle, endocrine, thyroid and other cell types.1-3
(±)-Bay K8644 (#B-350) is a highly pure, synthetic, and biologically active compound.
Applications
Citations
- Dahan, T. et al. (2017) Diabetes 66, 426.
- Teraoku, H. and Lenzen, S. (2017) J. Diabetes Res. 2017, 2309630.
- Gurgul-Convey, E. (2015) Biochem. Biophys. Res. Commun. 464, 13.
- He, S. et al. (2014) J. Neurosci. 34, 5261.
- Dominguez, B. et al. (2009) Am. J. Physiol. 296, E1148.
- Kaisman-Elbaz, T. et al. (2009) J. Cell. Physiol. 220, 222.
- Husch, A. et al. (2008) J. Neurophysiol. 99, 320.
- Hutchins, B.I. and Kalil, K. (2008) J. Neurosci. 28, 143.
- Perissinotti, P.P. et al. (2008) Eur. J. Neurosci. 27, 1333.
- Worrell, J.W. and Levine, R.B. (2008) J. Neurophysiol. 100, 868.
Specifications
Scientific Background
Related Products
Antibodies
- Anti-CaV1.1 (CACNA1S) (extracellular) Antibody (#ACC-314)
- Anti-CaV1.2 (CACNA1C) Antibody (#ACC-003)
- Anti-CaV1.2 (CACNA1C)-ATTO Fluor-488 Antibody (#ACC-003-AG)
- Guinea pig Anti-CaV1.2 (CACNA1C) Antibody (#ACC-003-GP (formerly AGP-001))
- Anti-Human CaV1.2 (CACNA1C) Antibody (#ACC-022)
- Anti-CaV1.2a (CACNA1C) Antibody (#ACC-013)
- Anti-CaV1.3 (CACNA1D) Antibody (#ACC-005)
- Guinea pig Anti-CaV1.3 (CACNA1D) Antibody (#ACC-005-GP (formerly AGP-061))
- Anti-CaV1.3 (CACNA1D) (extracellular) Antibody (#ACC-311)
Pharmacological tools
Explorer kits & Research packs
Need Help With This Product?
Our reagent specialists are here to help you find the best product for your application. Please call or email us and we will be happy to help you find the right product for the job.
Call us at
+972 2587 2202 or Email Us