Name: α-Asarone
Brand: Alomone Labs
SKU: A-260

Cat #: A-260

Alternative Name Asarone, trans-Isoasarone, Etherophenol

Lyophilized Powder yes

Bioassay Tested

Origin Acorus tatarinowii.

Source Natural

MW: 208.3

Purity: >99%

Effective concentration 1-500 µM.

Structure

Chemical name 1,2,4-trimethoxy-5-[(E)-prop-1-enyl]benzene.

Molecular formula C₁₂H₁₆O₃.

CAS No.: 2883-98-9

Activity α-Asarone 100 μM to 1 mM inhibits Na_V1.2 channel currents. It also blocks GABA(A) receptors in neurons¹. α-Asarone blocks corticosterone-induced anxiety-like behaviours via modulating TrkB signaling process².

References-Activity

Wang, Z.J. et al. (2014) Front. Pharmacol. 5, 1.
Lee, B. et al. (2014) Korean J. Physiol. Pharmacol. 18, 191.

Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Solubility 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions Up to four weeks at 4°C or three months at -20°C.

Our bioassay

Alomone Labs α-Asarone blocks Na_V1. 3 channels expressed in Xenopus oocytes.
A. Time course of Na_V1.3 current amplitude and inhibition by 100 and 500 µM α-Asarone (#A-260). Currents were elicited by application of a 100 ms voltage step to -10 mV (H.P= -100mV) every 10 seconds. B. Superimposed example traces of current responses before and during perfusion of 100 and 500 µM α-Asarone, as indicated.

References - Scientific background

Lee, B. et al. (2014) Korean J. Physiol. Pharmacol. 18, 191.
Park, S.H . et al. (2015) Int. J. Mol. Med. 35, 957.
Shin, J.W. et al. (2014) Biomol. Ther. (Seoul). 22,17.
Shi, H.X. et al. (2014) Evid. Based Complement. Alternat. Med. 2014, 682041.

Scientific background

α-Asarone is an active component of the Chinese medicinal plant Acorus tatarinouii Schott and exhibits a variety of pharmacological activities such as anti-hyperlipidemic, anti-coagulant, anti-tumor, anti-viral, and anti-inflammatory^1,2.

α-Asarone acts as a Na_V channel blocker, GABA(A) receptor blocker and TrkB receptor inhibitor and is available in the market in the form of tablets, capsules and injections¹.

The neuroprotective actions of α-asarone are exhibited through the blockade of N-methyl-D-aspartate (NMDA) receptor and by inhibition of nitric oxide (NO) overproduction in brain tissue. α-Asarone also exhibits anti-oxidative properties, reduces levels of superoxide dismutase (SOD), catalase, and glutathione peroxidase in the hippocampus against noise-stress and in various seizure models³.

Recent studies have shown that α-asarone has the ability to improve multiple physiological actions, to produce a variety of pharmacological actions in the CNS and modulate immune system functions. The anti-convulsant activity of α-asarone has been reported in several recent studies in epileptic seizure animal models³.

α-Asarone was shown to be effective in attenuating foam cell formation and enhancing cholesterol efflux⁴. In addition, it protects against angiotensin II-mediated damage of endothelial cells and can be developed for the prevention of injury to cardiovascular tissues².

α-Asarone may serve as a preventive and regenerative therapeutic agent to promote neurogenesis against age-related neurodegeneration and neurodegenerative disorders⁵.

Target Na_V channels, GABA(A) receptors, TrkB receptors, NMDA receptors

Lyophilized Powder

Last update: 06/11/2022

α-Asarone (#A-260) is a highly pure, natural, and biologically active compound.

Order Summary

α-Asarone

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Scientific Background

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