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Asarone, trans-Isoasarone, Etherophenol

An Antagonist of NaV Channels, GABA(A) Receptors, NMDA Receptors and an Inhibitor of TrkB Receptor

Cat #: A-260
Alternative Name Asarone, trans-Isoasarone, Etherophenol
Lyophilized Powder yes
  • Bioassay Tested
  • Origin Acorus tatarinowii.
    Source Natural
    MW: 208.3
    Purity: >99%
    Effective concentration 1-500 µM.
    Chemical name 1,2,4-trimethoxy-5-[(E)-prop-1-enyl]benzene.
    Molecular formula C12H16O3.
    CAS No.: 2883-98-9
    Activity α-Asarone 100 μM to 1 mM inhibits NaV1.2 channel currents. It also blocks GABA(A) receptors in neurons1. α-Asarone blocks corticosterone-induced anxiety-like behaviours via modulating TrkB signaling process2.
    1. Wang, Z.J. et al. (2014) Front. Pharmacol. 5, 1.
    2. Lee, B. et al. (2014) Korean J. Physiol. Pharmacol. 18, 191.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs α-Asarone blocks NaV1. 3 channels expressed in Xenopus oocytes. 
      Alomone Labs α-Asarone blocks NaV1. 3 channels expressed in Xenopus oocytes. 
      A. Time course of NaV1.3 current amplitude and inhibition by 100 and 500 µM α-Asarone (#A-260). Currents were elicited by application of a 100 ms voltage step to -10 mV (H.P= -100mV) every 10 seconds. B. Superimposed example traces of current responses before and during perfusion of 100 and 500 µM α-Asarone, as indicated.
    References - Scientific background
    1. Lee, B. et al. (2014) Korean J. Physiol. Pharmacol. 18, 191.
    2. Park, S.H. et al. (2015) Int. J. Mol. Med. 35, 957.
    3. Shin, J.W. et al. (2014) Biomol. Ther. (Seoul). 22,17.
    4. Shi, H.X. et al. (2014) Evid. Based Complement. Alternat. Med. 2014, 682041.
    Scientific background

    α-Asarone is an active component of the Chinese medicinal plant Acorus tatarinouii Schott and exhibits a variety of pharmacological activities such as anti-hyperlipidemic, anti-coagulant, anti-tumor, anti-viral, and anti-inflammatory1,2.

    α-Asarone acts as a NaV channel blocker, GABA(A) receptor blocker and TrkB receptor inhibitor and is available in the market in the form of tablets, capsules and injections1.

    The neuroprotective actions of α-asarone are exhibited through the blockade of N-methyl-D-aspartate (NMDA) receptor and by inhibition of nitric oxide (NO) overproduction in brain tissue. α-Asarone also exhibits anti-oxidative properties, reduces levels of superoxide dismutase (SOD), catalase, and glutathione peroxidase in the hippocampus against noise-stress and in various seizure models3.

    Recent studies have shown that α-asarone has the ability to improve multiple physiological actions, to produce a variety of pharmacological actions in the CNS and modulate immune system functions. The anti-convulsant activity of α-asarone has been reported in several recent studies in epileptic seizure animal models3.

    α-Asarone was shown to be effective in attenuating foam cell formation and enhancing cholesterol efflux4. In addition, it protects against angiotensin II-mediated damage of endothelial cells and can be developed for the prevention of injury to cardiovascular tissues2.

    α-Asarone may serve as a preventive and regenerative therapeutic agent to promote neurogenesis against age-related neurodegeneration and neurodegenerative disorders5.

    Target NaV channels, GABA(A) receptors, TrkB receptors, NMDA receptors
    Last update: 06/11/2022

    α-Asarone (#A-260) is a highly pure, natural, and biologically active compound.

    For research purposes only, not for human use



    Scientific Background

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