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α-Dendrotoxin is isolated from Dendroaspis angusticeps snake venom by modification of the procedures of Harvey1 and Benishin2 and purified to homogeneity. α-Dendrotoxin blocks KV1.1 and KV1.2 channels (IC50= 0.4 to 4 and 1.1 to 12 nM in oocytes respectively, with higher values for mammalian cells).4 In addition the toxin was shown to block also KV1.6 (IC50= 9-25 nM).4
α-Dendrotoxin was recently found to block ASIC curents in rat dorsal root ganglia (DRGs) with IC50 in the nM range5.
Alomone Labs α-Dendrotoxin inhibits KV1.2 channel currents in somatic MSN cells.Line scans taken 45– 60 µm from the soma show that blockade of KV1.2 channels with α-Dendrotoxin (#D-350) (0.5 µM) does not affect the amplitude of the bAP-evoked Ca2+ transient in dendrites (left traces in A and B) or adjacent spines (right traces in A and B) of either D1 or D2 MSNs (control: black, α-Dendrotoxin: red n = 5 each). Somatic voltage recordings from the MSNs shown in A) and B) demonstrate that spiking is enhanced by α-Dendrotoxin in both D1 and D2 MSNs (control: black, α-Dendrotoxin: red). Recordings were generated by injecting sequential depolarizing current steps at amplitudes just before and after rheobase potentials (100 and 125 pA, lower black line), (C and D).Adapted from Day, M. et al. (2008) J. Neurosci. 28, 11603. with permission of the Society for Neuroscience.
α-Dendrotoxin (#D-350) is a highly pure, natural, and biologically active peptide toxin.
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