Neuronal Adhesion Molecule Antibody Explorer Kit

A Screening Package of Neuronal Adhesion Molecule Antibodies for Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
Cat #: AK-430
Sizes: 24 Vials
Last update: 31/03/2019

Alomone Labs is pleased to offer the Neuronal Adhesion Molecule Antibody Explorer Kit (#AK-430). This Explorer Kit includes neuronal adhesion molecule antibodies, ideal for screening purposes.

For research purposes only, not for human use
Compounds
Scientific Background
Scientific Background

Neuroligins (NLGNs) are family of postsynaptic cell adhesion molecules that play an important role in synaptic development and function1. Four genes encode for the different members of the neuroligin family in mammals: NLGN 1-4, which are differentially enriched in postsynaptic specializations of synapses2. Neuroligin 2 (NLGN2) is expressed in neurons in the brain and also in pancreatic β cells where it facilitates insulin secretion3.

Neurexins (NRXNs) are a family of transmembrane, synaptic adhesion molecules. NRXNS were identified as receptors for α-latrotoxin, a presynaptic toxin that triggers massive neurotransmitter release4. Neurexins are largely presynaptic proteins that form a trans-synaptic cell-adhesion complex with postsynaptic neuroligins5. They are encoded by three genes (NRXN1, NRXN2 and NRXN3).

Nectins, which were originally identified as virus receptors, are members of the cell-cell adhesion molecule (CAM) family. They are Ca2+-independent immunoglobulin-like CAMs. The nectin family comprises four members, nectin-1, nectin-2, nectin-3 and nectin-4, which are encoded by the PVRL1, PVRL2, PVRL3 and PVRL4 genes, respectively6.  In the central nervous system, these cell adhesion molecules aggregate in formations, termed puncta adherentia junctions, which are mechanical adhesive sites that connect pre- and postsynaptic membranes7.

References
  1. Chubykin, A.A. et al. (2007) Neuron 54, 919.
  2. Kohl, C. et al. (2013) PLoS ONE 8, e5687.
  3. Suckow, A.T. et al. (2008) Endocrinology 149, 6006.
  4. Ichtchenko, K. et al. (1995) Cell 81, 435.
  5. Mosedale, M. et al. (2012) J. Biol. Chem287, 6350.
  6. Rikitake, Y. et al. (2012) J. Cell Sci. 125, 3713.
  7. Fantin, M. et al. (2013) PLoS One 8, e56897.
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