Cat #: C-280
Lyophilized Powder yes
Every lot is tried & tested in a relevant biological assay.
Origin Synthetic peptide
MW: 1883 Da.
Purity: >99% (HPLC)
Effective concentration 0.1-10 μM.
Modifications Disulfide bonds between Cys1-Cys9, Cys2-Cys15 and Cys4 -Cys16. Cys16 - C-terminal amidation.
Molecular formula C70H100N28O22S6.
Activity μ-Conotoxin KIIIA specifically and in some cases reversibly blocks TTX-sensitive mammalian voltage-dependent Na+ (NaV) channels1.
- Zhang, M.M. et al. (2007) J. Biol. Chem. 282, 30699.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to two weeks at 4°C or three months at -20°C.
- Alomone Labs μ-Conotoxin KIIIA differentially inhibits NaV1.4 and NaV1.2 channels heterologously expressed in Xenopus oocytes.A. Time course of μ-Conotoxin KIIIA (#C-280) action on NaV1.4 channels. Current amplitudes were plotted as a function of time. Oocyte membrane potential was held at -100 mV and 50 ms ramp to +50 mV was delivered every 10 seconds. 200 nM μ-Conotoxin KIIIA was perfused during the period marked in blue (100 seconds exposure). B. Example traces of NaV1.4 channel currents before (black) and during (blue) μ-Conotoxin KIIIA application. C. Time course of μ-Conotoxin KIIIA action on NaV1.2 channels. 1000 nM μ-Conotoxin KIIIA were perfused during the period marked in green (1000 seconds exposure). D. Example traces of NaV1.2 channel currents before (black) and during (green) μ-Conotoxin KIIIA application. E. Dose-response curves for NaV1.4 and NaV1.2 inhibition (upon 100 seconds exposure to the toxin; such as in A.).
References - Scientific background
Scientific background µ-Conotoxin KIIIA is a toxin originally isolated from the venom of Conus Kinoshitai1. µ-Conotoxin KIIIA specifically, and in some cases reversibly, blocks TTX-sensitive mammalian voltage-dependent Na+ (NaV) channels2. In addition, µ-Conotoxin KIIIA was found to act as an effective analgesic in an inflammatory pain assay in mice in vivo2,3.
Target TTX-sensitive Na+ channels
Net Peptide Content: 100%
Last update: 16/08/2020
µ-Conotoxin KIIIA (#C-280) is a highly pure, synthetic, and biologically active peptide toxin.
For research purposes only, not for human use
- Anti-SCN1A (NaV1.1) Antibody (#ASC-001)
- Guinea pig Anti-SCN1A (NaV1.1) Antibody (#AGP-043)
- Anti-SCN2A (NaV1.2) Antibody (#ASC-002)
- Anti-SCN2A (NaV1.2)-ATTO Fluor-594 Antibody (#ASC-002-AR)
- Anti-SCN3A (NaV1.3) (extracellular) Antibody (#ASC-023)
- Anti-SCN4A (NaV1.4) Antibody (#ASC-020)
- Anti-NaV1.6 (SCN8A) Antibody (#ASC-009)
- Anti-NaV1.7 (SCN9A) Antibody (#ASC-008)
- Guinea pig Anti-NaV1.7 (SCN9A) Antibody (#AGP-057)
- Anti-NaV1.7 (SCN9A) (extracellular) Antibody (#ASC-027)
Blockers/Antagonists: peptides/peptide toxins
Blockers/Antagonists: small molecules
Activators/Agonists: peptides/peptide toxins
Explorer kits & Research packs
Shipping and Ordering information