This product is freeze dried. All water molecules have been removed.
Every lot is tried & tested in a relevant biological assay.
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Alomone Labs ATX-II enhances hNaV1.5 currents in stably transfected HEK cells.hNaV1.5 currents were elicited by a 50 ms voltage step from the holding potential of -100 mV to -20 mV, applied every 20 sec, using whole-cell voltage clamp technique (bath solution contains TEA and pipette solution contains CsF). A. Time course, showing the effect of 0.05 nM, 0.5 nM, 5 nM and 50 nM ATX-II (#STA-700) on the current area, indicating a dose-dependent slowing of the hNaV1.5 inactivation. B. Superimposed traces of hNaV1.5 currents under control conditions and after 4-6 min perfusion with 0.05 nM, 0.5 nM, 5 nM and 50 nM ATX-II, as indicated.
- Romey, G. et al. (1976) Proc Natl. Acad. Sci. U.S.A. 73, 4055.
- Tesseraux, I. et al. (1987) Naunyn Schmiedebergs Arch. Pharmacol. 336, 232.
- Nishio, M. et al. (1991) Br. J. Pharmacol. 104, 504.
- Cannon, S.C. and Corey D.P. (1993) J. Physiol. 466, 501.
- Hoey, A. et al. (1994) Pharmacol. Toxicol. 75, 356.
- Chahine, M. et al. (1996) J. Membr. Biol. 152, 39.
- Fletcher, J. E. et al. (1999) Anesthesiology 90, 1294.
- Brand, S. et al. (2000) Eur. J. Neurosci. 12, 2387.
- Ravens, U. (1976) Naunyn-Schmiedeberg’s Arch. Pharmacol. 296, 73.
ATX-II is a 47 amino acid peptidyl toxin, originally isolated from Anemonia sulcata sea anemone venom. It is a potent neurotoxin, which modulates voltage-gated Na+ channel gating kinetics by delaying its inactivation and prolonging the action potential of excitable membranes. ATX-II has been used as a powerful activator of TTX-sensitive and insensitive Na+ channels in various excitable tissue and cell types (at concentration range of 10-100 nM).1-9
Effects of ATX-II on rabbit cardiomyocytes.Electrical stimulation-induced changes in [Na+]i in the absence (control) and presence of 5 nM ATX-II (#STA-700).Adapted from Kornyeyev, D. et al. (2016) Am. J. Physiol. 310, H426. with permission of The American Physiological Society.
ATX-II (#STA-700) is a highly pure, synthetic, and biologically active peptide toxin.
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- Anti-SCN1A (NaV1.1) Antibody (#ASC-001)
- Anti-SCN2A (NaV1.2)-ATTO-594 Antibody (#ASC-002-AR)
- Anti-SCN3A (NaV1.3) (extracellular) Antibody (#ASC-023)
- Anti-SCN4A (NaV1.4) Antibody (#ASC-020)
- Anti-NaV1.5 (SCN5A) (493-511) Antibody (#ASC-005)
- Guinea pig Anti-SCN11A (NaV1.9) Antibody (#AGP-030)
- Anti-Pan NaV Antibody (#ASC-003)
Blockers/Antagonists: peptides/peptide toxinsBlockers/Antagonists: small moleculesActivators/Agonists: peptides/peptide toxinsActivators/Agonists: small molecules