Lyophilized Powder This product is freeze dried. All water molecules have been removed.
Antigen Incl. This antibody is shipped with its antigen FREE of charge!
Renal Purinergic Receptor Antibody Explorer Kit (#AK-645) is a budget friendly screening package.
| Product Name | Cat # | Size |
|---|---|---|
Anti-P2X7 Receptor Antibody | APR-004 | 1 x 50 µl |
Anti-P2Y1 Receptor Antibody | APR-009 | 1 x 50 µl |
Anti-P2Y2 Receptor Antibody | APR-010 | 1 x 50 µl |
Anti-P2Y4 Receptor Antibody | APR-006 | 1 x 50 µl |
Anti-P2Y6 Receptor Antibody | APR-011 | 1 x 50 µl |
Anti-Adenosine A1 Receptor Antibody | AAR-006 | 1 x 50 µl |
Anti-Adenosine A2A Receptor Antibody | AAR-002 | 1 x 50 µl |
Anti-Adenosine A2B Receptor (extracellular) Antibody | AAR-003 | 1 x 50 µl |
The kidneys play a pivotal role in human physiology as they regulate heart and fluid homeostasis. They do so by regulating blood salt and mineral concentrations. This instrumental property of the kidneys is mediated by a small, yet very sophisticated functional unit, namely the nephron that filters unnecessary blood solutes into the urine while all necessary ions are carefully retained in the blood circulation. This "in and out" transition of ions across the vasculature is mediated by a battery of transmembrane protein-channels that facilitates the passage of solutes into and out of the blood circulation.
Purines are heterocyclic compounds with a broad range of physiologic effects. In the context of renal function, purines can trigger a variety of signaling pathways that control renal filtration rate. The vast majority of these signals are transmitted via distinct classes of transmembrane receptors that are generally divided into P1 and P2 super families. These receptors are further sub-grouped into A1, A2A, and A2B and A3 for the P1 class and respond to adenosine1, while P2 receptors are divided into ionotropic P2X receptors and metabotropic P2Y receptors that respond to ligands such as ATP or ADP1.
It is generally perceived that P1 receptors reduce renal filtration rate in response to adenosine by inducing vascular constriction2, while members of the P2Y family counter this effect by releasing the vascular relaxation compound nitric oxide3.
