Nodes of Ranvier Antibody Explorer Kit

A Screening Package of Nodes of Ranvier Antibodies Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
Cat #: AK-600
Sizes: 30 Vials
Last update: 24/04/2019

Nodes of Ranvier Antibody Explorer Kit (#AK-600) contains specific antibodies directed against proteins known to be localized at the Nodes of Ranvier.

For research purposes only, not for human use
Compounds
Product NameCat #Size
Anti-SCN1A (NaV1.1) Antibody
ASC-001 1 x 50 µl
Guinea pig Anti-SCN2A (NaV1.2) Antibody
AGP-026 1 x 50 µl
Anti-NaV1.6 (SCN8A) Antibody
ASC-009 1 x 50 µl
Anti-SCN1B (NaVβ1) (extracellular) Antibody
ASC-041 1 x 50 µl
Anti-SCN2B (NaVβ2) Antibody
ASC-007 1 x 50 µl
Anti-SCN4B (NaVβ4) (extracellular) Antibody
ASC-044 1 x 50 µl
Anti-KV1.1 (KCNA1) Antibody
APC-009 1 x 50 µl
Anti-KV3.1b (KCNC1) Antibody
APC-014 1 x 50 µl
Anti-KCNQ2 Antibody
APC-050 1 x 50 µl
Anti-KCNQ3 Antibody
APC-051 1 x 50 µl
Anti-ADAM22 (extracellular) Antibody
ANR-120 1 x 50 µl
Anti-Caspr2 Antibody
APZ-005 1 x 50 µl
Anti-Neurofascin Antibody
AIP-025 1 x 50 µl
Anti-PSD-93 Antibody
APZ-002 1 x 50 µl
Anti-PSD-95 Antibody
APZ-009 1 x 50 µl
Note A guinea pig polyclonal antibody (#AGP-026) is included in this Explorer Kit. Please take into account when reacting with a secondary antibody.
Scientific Background
    • Myelinated axons of the peripheral and central nervous systems are divided into molecularly distinct excitable domains, including paranodal axoglial junctions, juxtaparanodes, internodes and the nodes of ranvier. Nodes of Ranvier are spatially near myelin sheaths and are interspersed at regular distances along the axon.

      Nodes of ranvier are responsible for regenerating the action potential as it propagates along the myelinated axon away from the soma. Action potential propagation in myelinated nerves requires clustered voltage gated sodium (Na+) and potassium (K+) channels. In addition, nodes of ranvier are also enriched with the cytoskeletal and scaffolding proteins ankyrin G (ankG) and βIV spectrin. These proteins link the sodium and potassium channels to the underlying cytoskeleton1,2.

      Nodes of ranvier play an important role in normal neural physiology. Disruption of the nodes is implicated in a variety of neurological disorders including stroke, epilepsy, and traumatic injury1.

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