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611 Results for "pain".
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Small Molecules (106) Toxins (58) Proteins (7) Antibodies (359) Kits & Packs (35)
Antibodies
The Negative Control Antigen was replaced with the Blocking Peptide product line, offering superior QC and performance.
IBA1/AIF1 Blocking Peptide (#BLP-CS010)
Anti-GPR142 (extracellular)-FITC Antibody
Cat #: AGR-082-F
Applications:
fc, lci
Host: Rabbit
Alternative names: G-Protein Coupled Receptor 142, Probable G-Protein Coupled Receptor 142, PGR2
Anti-Neuronal Pentraxin 2 (NPTX2) Antibody
Cat #: ANR-192
Applications:
ihc, wb, icc*, ip*
Host: Rabbit
Alternative names: Neuronal Pentraxin-2, NP2, Neuronal Activity-Regulated Pentaxin, NARP
Neuronal Pentraxin 2 (NPTX2) Blocking Peptide (#BLP-NR192)
Anti-Tetraspanin 2 (extracellular) Antibody
Cat #: ANR-188
Applications:
ifc, ihc, lci, wb, icc*, ip*
Host: Rabbit
Alternative names: Tetraspan NET-3, TSPAN2
Tetraspanin 2 (extracellular) Blocking Peptide (##BLP-NR188)
Anti-5HT6 Receptor (HTR6) (extracellular) Antibody
Cat #: ASR-038
Applications:
ihc, wb, icc*, ifc*, ip*, lci*
Host: Rabbit
Alternative names: 5-Hydroxytryptamine Receptor 6, Serotonin Receptor 6, 5-HT-6, 5HT6R
5HT6 Receptor (HTR6) (extracellular) Blocking Peptide (#BLP-SR038)
Anti-TREM2 (extracellular)-APC Antibody
Cat #: ANR-018-APC
Applications:
fc, lci
Host: Rabbit
Alternative names: Triggering receptor expressed on myeloid cells 2, Triggering receptor expressed on monocytes 2
Anti-CD38 (extracellular) Antibody
Cat #: ANT-068
Applications:
ifc, ihc, lci, wb, icc*, ip*
Host: Rabbit
Alternative names: ADP-Ribosyl Cyclase 1, ADPRC 1, Cyclic ADP-Ribose Hydrolase 1, cADPR hydrolase 1, CADPR1
CD38 (extracellular) Blocking Peptide (#BLP-NT068)
Guinea Pig Anti-Orexin Receptor 1 Antibody
Cat #: AOR-001-GP
Applications:
ihc, wb, icc*, ip*
Host: Guinea Pig
Alternative names: OX1R, Hypocretin receptor type 1, HCRTR1
Orexin Receptor 1 Blocking Peptide (#BLP-OR001)
Anti-SCN7A (NaX) Antibody
Cat #: ASC-050
Applications:
ihc, wb, icc*, ip*
Host: Rabbit
Alternative names: Sodium Channel Protein Type 7 Subunit Alpha, Putative voltage-gated sodium channel subunit alpha Nax, SCN6A, Nav2.1, Nav2.2
SCN7A (NaX) Blocking Peptide (#BLP-SC050)
Anti-DSCAM (extracellular) Antibody
Cat #: ANR-046
Applications:
ihc, lci, wb, icc*, ifc*, ip*
Host: Rabbit
Alternative names: Down Syndrome Cell Adhesion Molecule, DS Cell Adhesion Molecule, CHD2
DSCAM (extracellular) Blocking Peptide (#BLP-NR046)
Anti-BMPR1A (extracellular) Antibody
Cat #: ABR-043
Applications:
ifc, ihc, lci, wb, icc*, ip*
Host: Rabbit
Alternative names: Bone Morphogenetic Protein Receptor Type-1A, Activin Receptor-Like Kinase 3, ALK3, Serine/Threonine-Protein Kinase Receptor R5, SKR5, CD292
BMPR1A (extracellular) Blocking Peptide (#BLP-BR043)
Anti-Piezo1 (extracellular)-APC Antibody
Cat #: APC-087-APC
Applications:
fc, lci
Host: Rabbit
Alternative names: Piezo-type mechanosensitive ion channel component 1, Protein FAM38A, Mib, Membrane protein induced by beta-amyloid treatment
Anti-CD9 (extracellular) Antibody
Cat #: ANR-209
Applications:
ifc, ihc, lci, wb, icc*, ip*
Host: Rabbit
Alternative names: Tetrapanin-29, TSPAN29, Leukocyte Antigen MIC3, MIC3
CD9 (extracellular) Blocking Peptide (#BLP-NR209)
Anti-Beta 2 Na+/K+ ATPase (extracellular)-FITC Antibody
Cat #: ANP-012-F
Applications:
fc, lci
Host: Rabbit
Alternative names: ATP1B2, Sodium/potassium-transporting ATPase subunit beta-2, Adhesion molecule on glia, AMOG
Anti-P2Y12 Receptor (extracellular)-APC Antibody
Cat #: APR-020-APC
Applications:
fc, lci
Host: Rabbit
Alternative names: P2Y purinoceptor 12, P2RY12, P2Y receptor
Anti-CD81 (extracellular)-FITC Antibody
Cat #: ANR-211-F
Applications:
fc, lci
Host: Rabbit
Alternative names: Tetraspanin-28, TSPAN28, Target of the Antiproliferative Antibody 1, TAPA-1
Guinea Pig Anti-CHRM3 Antibody
Cat #: AMR-006-GP
Applications:
ihc, wb, icc*, ip*
Host: Guinea Pig
Alternative names: Cholinergic receptor muscarinic 3, Acetylcholine receptor muscarinic 3, M3 AChR
CHRM3 Blocking Peptide (#BLP-MR006)
Anti-Neuropeptide S Receptor (extracellular)-FITC Antibody
Cat #: ANR-029-F
Applications:
fc, lci
Host: Rabbit
Alternative names: NPSR1, G-Protein Coupled Receptor 154, GPR154, G-Protein Coupled Receptor for Asthma Susceptibility, GPRA
Anti-C3aR1 (extracellular)-FITC Antibody
Cat #: AAR-036-F
Applications:
fc, lci
Host: Rabbit
Alternative names: Complement C3a Receptor 1, C3AR, C3a Anaphylatoxin Chemotactic Receptor
Kits & Packs
TTX-Sensitive NaV Channel Blocker Explorer Kit
Cat #: EK-105
10 Vials
Angiotensin II Receptor Pharmacology Explorer Kit
Cat #: EK-405
6 Vials
KCNQ (KV7) Channel Basic Research Pack
Cat #: ESB-503
14 Vials
P2X7 Receptor Antagonist Explorer Kit
Cat #: EK-410
13 Vials
P2X7 Receptor Basic Research Pack
Cat #: ESB-710
7 Vials
P2X7 Receptor Premium Research Pack
Cat #: ESP-710
10 Vials
P2X7 Receptor Deluxe Research Pack
Cat #: ESD-710
15 Vials
K+ Channel Antibodies for Pain Research Explorer Kit
Cat #: AK-390
25 Vials
K+ Channel Blockers for Pain Research Explorer Kit
Cat #: EK-390
14 Vials
NaV Channel Antibodies for Pain Research Explorer Kit
Cat #: AK-365
28 Vials
Classical Ion Channel Blockers for Pain Research Explorer Kit
Cat #: EK-355
24 Vials
KV Channel Antibodies for Pain Research Explorer Kit
Cat #: AK-385
12 Vials
CaV Channel Antibodies for Pain Research Explorer Kit
Cat #: AK-360
12 Vials
CaV Channel Blockers for Pain Research Explorer Kit
Cat #: EK-385
13 Vials
iGluR Antibodies for Pain Research Explorer Kit
Cat #: AK-395
16 Vials
nAChR Antibodies for Pain Research Explorer Kit
Cat #: AK-375
8 Vials
KV Channel Blockers for Pain Research Explorer Kit
Cat #: EK-380
9 Vials
NaV Channel Blockers for Pain Research Explorer Kit
Cat #: EK-375
11 Vials
TRP Channel Antibodies for Pain Research Explorer Kit
Cat #: AK-370
22 Vials
Purinergic Receptor Antibodies for Pain Research Explorer Kit
Cat #: AK-400
26 Vials
P2X Receptor Antibodies for Pain Research Explorer Kit
Cat #: AK-380
16 Vials
Ion Channel Activators for Pain Research Explorer Kit
Cat #: EK-395
8 Vials
GPCR Pain-Related Antibody Explorer Kit
Cat #: AK-545
16 Vials
Pain-Related DRG Marker Antibody Kit
Cat #: AK-550
18 Vials
TTX-Resistant NaV Channel Blocker Explorer Kit
Cat #: EK-106
5 Vials
Shaker (KV)-Related Channel Blocker Explorer Kit
Cat #: EK-108
15 Vials
ASIC3 Channel Basic Research Pack
Cat #: ESB-201
6 Vials
ASIC3 Channel Premium Research Pack
Cat #: ESP-201
11 Vials
NaV1.7 Channel Basic Research Pack
Cat #: ESB-001
7 Vials
NaV1.7 Channel Deluxe Research Pack
Cat #: ESD-001
14 Vials
NaV1.7 Channel Premium Research Pack
Cat #: ESP-001
11 Vials
Mechanosensitive Ion Channel Antibody Explorer Kit
Cat #: AK-234
32 Vials
Mechanosensitive KCNK (K2P) Channel Antibody Explorer Kit
Cat #: AK-306
10 Vials
Opioid Receptor Antibody Explorer Kit
Cat #: AK-520
8 Vials
mGluR1 Antagonist Explorer Kit
Cat #: EK-250
12 Vials
Related Results
Ion Channels and Pain
Modulator - Issue No. 26
Pain perception becomes a burden and ceases to be physiologically beneficial when the threat causing the pain is gone and the pain sensations remain. Such pathological, chronic conditions appear due…
When Pain Aids Cancer
…not only promote the growth and activity of these nerves but also ramp up their sensitivity to painful stimuli. Sensitizing the Pain Detectors Melanomas actively influence the behavior of neighboring…
NaV Channels and Pain
Modulator - Issue No. 27
…pain opens a gateway for the development of specific sodium-channel inhibiting agents for the treatment of chronic pain2. NaV Channels and Pain Resurgent Na+ currents are currents activated during repolarization,…
Narirutin: Satsuma’s Chemical for Banishing Pain
Neuropathic pain is chronic and widespread, affecting millions worldwide. Despite its prevalence, the treatments for neuropathic pain can be limited in their efficacy or associated with adverse side effects. But…
Contribution of Ion Channels in Pain Sensation
Modulator - Issue No. 19
…of normal function after injury or disease2,7,8. Nociceptive pain can be subdivided into somatic pain (cutaneous or deep tissues) and visceral pain (pain in the internal organs). Nociceptive pain occurs…
Research Roundup #7 – Pain suppression, SARS-CoV-2 resistance, and antihistamines versus cancer cells
In this installment, there’s an exciting bit of research that’s uncovered a potential therapeutic target for chronic pain in people with irritable bowel syndrome (IBS). There’s also work into calcium…
Research Roundup #6 – exploring diabetic pain and the diabetic heart
There’s a focus on diabetes and some great work using rat and mouse models in this Research Roundup. Learn about a cherry tree and diabetic pain (well, a compound isolated…
Venom Peptides and their Mimetics as Potential Drugs
Modulator - Issue No. 19
…possible drugs for the treatment of pain, epilepsy, cardiovascular disorders, cancer and other neurological disorders (See Table), (for recent and comprehensive reviews please refer to references 1-10). Pain Recurrent pain…
Resiniferatoxin: the hottest chemical you’re not using
…in diseases like knee osteoarthritis.3 Fixing knee pain The pain-relieving benefit of RTX has already been explored in canine research where the pain relief lasted for months to even years4…
The Dual Role of NaV1.7
in Osteoarthritis
…pain behaviors. Conversely, deleting NaV1.7 in DRG neurons only mitigated pain, without influencing OA’s structural damage. Since the knockout work showed that NaV1.7 deletion had positive effects, this raised the…
TRPV1 Antibodies, Agonists, and Antagonists
…by TRPV1, providing analgesic effects. TRPV1 blockers have been explored as potential treatments for chronic pain conditions, such as neuropathic pain and inflammatory pain. In research, TRPV1 blockers are used…
Acid-Sensing Ion Channels: Structure and Function
Modulator - Issue No. 18
…pain sensation, primarily high intensity pain produced by heat and acid10, 24. Other studies have shown a strong correlation between ASIC3 function and cardiac pain. During a heart attack the…
Tickling the Heart and the Nervous System with the Funny Current
Modulator - Issue No. 24
…pain sensation among some patients. As HCN channels have been identified in DRGs, their involvement was investigated regarding pain sensation23. Immunohistochemistry sections demonstrated that all four HCN channels are expressed…
The Transient Receptor Potential (TRP) Ion Channels
Modulator - Issue No. 20
TRP channels show diverse biophysical properties and gating mechanisms and were found to play an important role in sensory physiology, being involved in almost every sensory signal initiation from pain…
Voltage-Gated Sodium Channel Modulators
…early stages of AD. Learn More Satsuma’s Chemical for Banishing Pain The current treatments for neuropathic pain are often either not very good or associated with adverse side effects. Some…
The Transient Receptor Potential Superfamily: Antibodies in Action
Modulator - Issue No. 22
…roles in Ca2+ homeostasis, pain, and tumorigenesis, among others, TRP channels have lately been subjects of intensive research. Alomone Labs has developed antibodies against unique epitopes, intracellular as well as…
Mainstream- Fringe- and Patho- Physiology of Voltage Dependent Na+ (NaV) Channels
Modulator - Issue No. 20
…in different pathophysiological conditions. For example, changes in the levels of functional NaV channel expression forms the basis of changes in conduction properties of DRG neurons associated with chronic pain…
BDNF – Second Best?
Neurotrophin Pathways - Issue No. 1
…levels. These include, synapse formation and modulation of synaptic elements during neuronal development, injury, repair or plasticity associated with sleep control, pain perception, learning and memory, as well as with…
ENaC and ASIC Channels at a Glance
Modulator - Issue No. 25
…ASIC1 knock out mice DRGs revealing that the interaction is specific and authentic 10 . p11 has also been attributed to pain sensation 19 . In…
NGF: One Molecule, Multiple Functions
Neurotrophin Pathways - Issue No. 1
…from reference 8 with permission of The Society for Neuroscience. The Involvement of NGF in Pain Conditions Tissue inflammation is typically accompanied by hyperalgesia and pain. It increases the sensitivity…
Venom Toxins as Ion Channel Research Tools
Modulator - Issue No. 21
…a number of indications, including pain, cardiovascular, and neurological pathologies.5,6 Due to the huge scope of this subject, this review we will highlight only a small fraction of examples for…
TTA-P2 and TTA-A2: Specific and Potent CaV3 Channel Blockers
Modulator - Issue No. 27
…each with various problems. Channelopathies associated with T-type channels include autism, epilepsy, hypertension, hyperaldosteronism, chronic pain, and neuropathic pain. Due to their important physiological roles, and to the increasing number…
Acid-Sensing Ion Channels (ASICs)
…and ASIC3. ASIC1 subtypes are primarily found in neurons of the central nervous system, where they play a role in synaptic transmission and pain perception. ASIC2 subtypes are more widely…
In Focus: NGF Neutralization
Neurotrophin Pathways - Issue No. 2
…(2006) Annu. Rev. Neurosci. 29, 507. Sabsovich, I. et al. (2008) Pain 138, 47. Sevcik, M.A. et al. (2005) Pain 115, 128. Shelton, D.L. et al. (2005) Pain 116, 8….
Pharmacological Reagents
…a doubt increased tremendously over the past few decades. Ion channels are important therapeutic targets in numerous pathophysiological conditions, from epilepsy, migraine, pain, neurodegenerative diseases, and heart conditions just to…
Ion Channel Modulation by G-Protein Coupled Receptors
Modulator - Issue No. 21
…have been used in eastern medicine for many years as pain relievers.53 To date, two specific cannabinoid receptors, known as CB1 and CB2, have been identified. Both of them are…
Voltage Dependent Ca2+ (CaV) Channels
Modulator - Issue No. 20
…most interesting example is related to pain control with regard to an N-type channel (CaV2.2) variant, which is selectively expressed in sensory neurons in DRG29. CaV2 channels are modulated by…
GABA (B) Receptors: an Example of Subtle Modulations in a Neurotransmitter System
GPCR Pathways - Issue No. 4
…in treating conditions related to hyperexcitability, such as pain. Antagonists on the other hand block endogenous inhibitory actions of GABA and lead to greater activity of specific synapses10. Baclofen, a…
Molecular Diversity of P2 Receptors
Modulator - Issue No. 14
…receptors8,9. Since ATP, released due to tissue damage, can evoke a sensation of pain11, a specific role in the sensing of damage (nociception) has been suggested for this isoform. Indeed,…
The Purinergic P2X Receptors
Modulator - Issue No. 17
…Santa Lucia, Italy. The P2X Receptors and the Pain Pathway Data accumulated in the last several years implicates the involvement of P2X receptors in pain pathways. Attention was focused in…
T-Type Ca2+ Channels
Modulator - Issue No. 26
T-type Ca2+ channels are at the heart of numerous research topics such as pain and epilepsy. This paper aims at describing various aspects of CaV3 regulation, their role in LTP,…
In Focus: Ionotropic Glutamate Receptors
Modulator - Issue No. 25
…Overly active NMDA receptors could instigate some neurological disorders 13 and neuropathic pain 27 . Conversely, underactive NMDA receptors may underlie neurodevelopmental disorders such as schizophrenia…
Tetrodotoxin – A Powerful Molecular Tool in Excitable Tissues
Modulator - Issue No. 25
…This expression was relatively transient and TTX was able to counteract this expression leading to hyperexcitability and pain17. Electrical activity in the form of AP also affects neuronal survival. In…
Ionotrophic ATP (P2X) Receptors
Modulator - Issue No. 23
…CFA into the plantar surface of the hindpaw, an inflammatory pain model (bottom right). Scale bars, 200µm.Adapted from reference 24 with permission of Nature Publishing Group. Figure 3. in vivo…
Cannabinoid Signaling in the Nervous System
GPCR Pathways - Issue No. 5
Cannabinoids have been used in Eastern medicine for many years as pain relievers. Δ9-tetrahydrocannabinol (THC), the major psychoactive compound in marijuana and hashish, has been shown to interact with two…